UniProt Accession

 ERR1_HUMAN; P11474; Q14514 

Genbank Protein ID

 X51416; L38487; AP001453 

Genbank Nucleotide ID

 CAA35778.1; AAB17015.1 

Protein Name

 Steroid hormone receptor ERR1 

Protein Synonyms/Alias

 Estrogen receptor-like 1; Estrogen-related receptor alpha; ERR-alpha; Nuclear receptor subfamily 3 group B member 1 

Gene Name

 ESRRA 

Gene Synonyms/Alias

 ERR1; ESRL1; NR3B1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
14	GIEPLYIKAEPASPD	sumoylation	[1, 2]
76	LVLSSLPKRLCLVCG	ubiquitination	[3]
129	EITKRRRKACQACRF	acetylation	[4]
138	CQACRFTKCLRVGML	acetylation	[4]
146	CLRVGMLKEGVRLDR	ubiquitination	[3]
160	RVRGGRQKYKRRPEV	acetylation	[4]
162	RGGRQKYKRRPEVDP	acetylation	[4]
403	LAHFYGVKLEGKVPM	sumoylation	[1, 2]
403	LAHFYGVKLEGKVPM	ubiquitination	[3]

Reference

 [1] Phosphorylation-dependent sumoylation of estrogen-related receptor alpha1.
 Vu EH, Kraus RJ, Mertz JE.
 Biochemistry. 2007 Aug 28;46(34):9795-804. [PMID: 17676930]
 [2] Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif.
 Tremblay AM, Wilson BJ, Yang XJ, Giguère V.
 Mol Endocrinol. 2008 Mar;22(3):570-84. [PMID: 18063693]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha.
 Wilson BJ, Tremblay AM, Deblois G, Sylvain-Drolet G, Giguère V.
 Mol Endocrinol. 2010 Jul;24(7):1349-58. [PMID: 20484414] 

Functional Description

 Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. 

Sequence Annotation

 DNA_BIND 76 151 Nuclear receptor.
 ZN_FING 79 99 NR C4-type.
 ZN_FING 115 134 NR C4-type.
 REGION 1 76 Repressor domain.
 REGION 206 402 Ligand binding domain.
 REGION 403 423 AF-2 domain.
 MOD_RES 19 19 Phosphoserine.
 MOD_RES 22 22 Phosphoserine.
 MOD_RES 129 129 N6-acetyllysine; by PCAF/KAT2B.
 MOD_RES 138 138 N6-acetyllysine; by PCAF/KAT2B.
 MOD_RES 160 160 N6-acetyllysine; by PCAF/KAT2B.
 MOD_RES 162 162 N6-acetyllysine; by PCAF/KAT2B.
 CROSSLNK 14 14 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 403 403 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Receptor; Reference proteome; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 423 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; TAS:ProtInc.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0005496; F:steroid binding; IEA:InterPro.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0051216; P:cartilage development; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:0045667; P:regulation of osteoblast differentiation; IEA:Compara.
 GO:0045670; P:regulation of osteoclast differentiation; IEA:Compara.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome. 

Interpro

 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR027289; Oest-rel_rcp.
 IPR024178; Oest_rcpt/oest-rel_rcp.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 

Pfam

 PF00104; Hormone_recep
 PF00105; zf-C4 

SMART

 SM00430; HOLI
 SM00399; ZnF_C4 

PROSITE

 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 

PRINTS

 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.