CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040571
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Adenylate cyclase type 6 
Protein Synonyms/Alias
  
Gene Name
 Adcy6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
127LVQVFQSKQFRSAKLubiquitination[1]
568EEKAMLAKLQRTRANubiquitination[1]
609MGIDDSSKDNRGAQDubiquitination[1]
934KLQATGEKEEMEELQubiquitination[1]
1101AGVIGARKPQYDIWGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lyase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1168 AA 
Protein Sequence
MSWFSGLLVP KVDERKTAWG ERNGQKRPRH ANRASGFCAP RYMSCLKNAE PPSPTPAAHT 60
RCPWQDEAFI RRAGPGRGVE LGLRSVALGF DDTEVTTPMG TAEVAPDTSP RSGPSCWHRL 120
VQVFQSKQFR SAKLERLYQR YFFQMNQSSL TLLMAVLVLL MAVLLTFHAA PAQPQPAYVA 180
LLTCASVLFV VLMVVCNRHS FRQDSMWVVS YVVLGILAAV QVGGALAANP HSPSAGLWCP 240
VFFVYITYTL LPIRMRAAVL SGLGLSTLHL ILAWQLNSSD PFLWKQLGAN VVLFLCTNAI 300
GVCTHYPAEV SQRQAFQETR GYIQARLHLQ HENRQQERLL LSVLPQHVAM EMKEDINTKK 360
EDMMFHKIYI QKHDNVSILF ADIEGFTSLA SQCTAQELVM TLNELFARFD KLAAVRENHC 420
LRIKILGDCY YCVSGLPEAR ADHAHCCVEM GVDMIEAISL VREVTGVNVN MRVGIHSGRV 480
HCGVLGLRKW QFDVWSNDVT LANHMEAGGR AGRIHITRAT LQYLNGDYEV EPGRGGERNA 540
YLKEQCIETF LILGASQKRK EEKAMLAKLQ RTRANSMEGL MPRWVPDRAF SRTKDSKAFR 600
QMGIDDSSKD NRGAQDALNP EDEVDEFLGR AIDARSIDQL RKDHVRRFLL TFQREDLEKK 660
YSRKVDPRFG AYVACALLVF CFICFIQLLV FPYSTLILGI YAAIFLLLLV TVLICAVCSC 720
GSFFPKALQR LSRNIVRSRV HSTAVGIFSV LLVFISAIAN MFTCNHTPIR TCAARMLNLT 780
PADVTACHLQ QLNYSLGLDA PLCEGTAPTC SFPEYFVGNV LLSLLASSVF LHISSIGKLA 840
MTFILGFTYL VLLLLGPPAA IFDNYDLLLG VHGLASSNET FDGLDCPAVG RVALKYMTPV 900
ILLVFALALY LHAQQVESTA RLDFLWKLQA TGEKEEMEEL QAYNRRLLHN ILPKDVAAHF 960
LARERRNDEL YYQSCECVAV MFASIANFSE FYVELEANNE GVECLRLLNE IIADFDEIIS 1020
EERFRQLEKI KTIGSTYMAA SGLNASTYDQ VGRSHITALA DYAMRLMEQM KHINEHSFNN 1080
FQMKIGLNMG PVVAGVIGAR KPQYDIWGNT VNVSSRMDST GVPDRIQVTT DLYQVLAAKG 1140
YQLECRGVVK VKGKGEMTTY FLNGGPSS 1168 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005886; C:plasma membrane; TAS:MGI.
 GO:0004016; F:adenylate cyclase activity; IDA:MGI.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0007190; P:activation of adenylate cyclase activity; TAS:MGI.
 GO:0071870; P:cellular response to catecholamine stimulus; IEA:Compara.
 GO:0071380; P:cellular response to prostaglandin E stimulus; IEA:Compara.
 GO:0007212; P:dopamine receptor signaling pathway; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS.
 IPR009398; Adenylate_cyclase-like. 
Pfam
 PF06327; DUF1053
 PF00211; Guanylate_cyc 
SMART
 SM00044; CYCc 
PROSITE
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2 
PRINTS