| Tag | Content |
|---|
| CPLM ID | CPLM-015808 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein NLRC3 |
Protein Synonyms/Alias | CARD15-like protein; Caterpiller protein 16.2; CLR16.2; Nucleotide-binding oligomerization domain protein 3 |
Gene Name | NLRC3 |
Gene Synonyms/Alias | NOD3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 716 | GKDCRIQKISLAENQ | ubiquitination | [1] |
|
Reference | [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA. Mol Cell Proteomics. 2012 May;11(5):148-59. [ PMID: 22505724] |
Functional Description | May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA. |
Sequence Annotation | DOMAIN 139 460 NACHT.
REPEAT 617 639 LRR 1.
REPEAT 641 663 LRR 2.
REPEAT 665 688 LRR 3.
REPEAT 693 716 LRR 4.
REPEAT 721 744 LRR 5.
REPEAT 749 772 LRR 6.
REPEAT 777 800 LRR 7.
REPEAT 805 828 LRR 8.
REPEAT 833 856 LRR 9.
REPEAT 861 884 LRR 10.
REPEAT 889 912 LRR 11.
REPEAT 917 940 LRR 12.
REPEAT 945 968 LRR 13.
REPEAT 973 996 LRR 14.
REPEAT 1001 1029 LRR 15.
REPEAT 1031 1052 LRR 16.
NP_BIND 145 152 ATP (Potential). |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Leucine-rich repeat; Nucleotide-binding; Polymorphism; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1065 AA |
Protein Sequence | MEMDAPRPPS LAVPGAASRP GRLLDGGHGR QQVQALSSQL LEVIPDSRKQ EVRTGREAGQ 60
GHGTGSPAEQ VKALMDLLAG KGSQGSQAPQ ALDRTPDAPL GPCSNDSRIQ RHRKALLSKV 120
GGGPELGGPW HRLASLLLVE GLTDLQLREH DFTQVEATRG GGHPARTVAL DRLFLPLSRV 180
SVPPRVSITI GVAGMGKTTL VRHFVRLWAH GQVGKDFSLV LPLTFRDLNT HEKLCADRLI 240
CSVFPHVGEP SLAVAVPARA LLILDGLDEC RTPLDFSNTV ACTDPKKEIP VDHLITNIIR 300
GNLFPEVSIW ITSRPSASGQ IPGGLVDRMT EIRGFNEEEI KVCLEQMFPE DQALLGWMLS 360
QVQADRALYL MCTVPAFCRL TGMALGHLWR SRTGPQDAEL WPPRTLCELY SWYFRMALSG 420
EGQEKGKASP RIEQVAHGGR KMVGTLGRLA FHGLLKKKYV FYEQDMKAFG VDLALLQGAP 480
CSCFLQREET LASSVAYCFT HLSLQEFVAA AYYYGASRRA IFDLFTESGV SWPRLGFLTH 540
FRSAAQRAMQ AEDGRLDVFL RFLSGLLSPR VNALLAGSLL AQGEHQAYRT QVAELLQGCL 600
RPDAAVCARA INVLHCLHEL QHTELARSVE EAMESGALAR LTGPAHRAAL AYLLQVSDAC 660
AQEANLSLSL SQGVLQSLLP QLLYCRKLRL DTNQFQDPVM ELLGSVLSGK DCRIQKISLA 720
ENQISNKGAK ALARSLLVNR SLTSLDLRGN SIGPQGAKAL ADALKINRTL TSLSLQGNTV 780
RDDGARSMAE ALASNRTLSM LHLQKNSIGP MGAQRMADAL KQNRSLKELM FSSNSIGDGG 840
AKALAEALKV NQGLESLDLQ SNSISDAGVA ALMGALCTNQ TLLSLSLREN SISPEGAQAI 900
AHALCANSTL KNLDLTANLL HDQGARAIAV AVRENRTLTS LHLQWNFIQA GAAQALGQAL 960
QLNRSLTSLD LQENAIGDDG ACAVARALKV NTALTALYLQ VASIGASGAQ VLGEALAVNR 1020
TLEILDLRGN AIGVAGAKAL ANALKVNSSL RRLNLQENSL GMDGAICIAT ALSGNHRLQH 1080
INLQGNHIGD SGARMISEAI KTNAPTCTVE M 1111 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; IDA:UniProtKB. GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB. GO:0042110; P:T cell activation; IEP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |