UniProt Accession

 CEP72_HUMAN; Q9P209; B4DR26; Q9BV03; Q9BWM3; Q9NVR4 

Genbank Protein ID

 AB040952; AK001427; AK299072; BC000132; BC001750 

Genbank Nucleotide ID

 BAA96043.1; BAA91685.1; BAG61138.1; AAH00132.1; AAH01750.2 

Protein Name

 Centrosomal protein of 72 kDa 

Protein Synonyms/Alias

 Cep72 

Gene Name

 CEP72 

Gene Synonyms/Alias

 KIAA1519 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
57	LMSLTGLKSLDLSRN	ubiquitination	[1]
115	FRLNPVVKVEPDYRL	ubiquitination	[1, 2, 3, 4]
130	FVVHLLPKLQQLDDR	ubiquitination	[1]
160	SEDSLDSKESVPASL	ubiquitination	[1]
168	ESVPASLKEGRPHHP	ubiquitination	[1]
267	CRGCCLEKMPWSQLC	ubiquitination	[1, 5]
314	EDSASSQKLDLSGEM	ubiquitination	[1]
364	THGSSVPKESLSRQD	ubiquitination	[1]
414	SHSALPGKKTALQAA	ubiquitination	[1]
415	HSALPGKKTALQAAL	ubiquitination	[1]
482	GSLALESKSLQSRLA	ubiquitination	[1, 5]
522	DLRQHLDKSLEENSR	ubiquitination	[1]
531	LEENSRLKSLLLSMK	ubiquitination	[1]
539	SLLLSMKKEVKSADT	ubiquitination	[1]
542	LSMKKEVKSADTAAT	ubiquitination	[1]
562	AGLQTSVKRLCGEIV	ubiquitination	[1]
628	HWSYQELKKTMALFP	ubiquitination	[1, 5]
629	WSYQELKKTMALFPH	ubiquitination	[1, 4, 5]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ/PLK1S1, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). 

Sequence Annotation

 REPEAT 29 50 LRR 1.
 REPEAT 55 76 LRR 2.
 REPEAT 77 98 LRR 3.
 DOMAIN 111 150 LRRCT.
 MOD_RES 237 237 Phosphoserine.  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Leucine-rich repeat; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 647 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0033566; P:gamma-tubulin complex localization; IMP:UniProtKB.
 GO:0007051; P:spindle organization; IMP:UniProtKB. 

Interpro

 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003603; U2A'_phosphoprotein32A_C. 

Pfam

 PF12799; LRR_4 

SMART

 SM00446; LRRcap 

PROSITE

 PS51450; LRR 

PRINTS