CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012767
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Intermediate filament protein ifb-1 
Protein Synonyms/Alias
 Cel IF B1; Intermediate filament protein B1; IF-B1 
Gene Name
 ifb-1 
Gene Synonyms/Alias
 F10C1.2 
Created Date
 July 27, 2013 
Organism
 Caenorhabditis elegans 
NCBI Taxa ID
 6239 
Lysine Modification
Position
Peptide
Type
References
491DPNGKFIKLENSHRNsumoylation[1]
Reference
 [1] SUMO regulates the assembly and function of a cytoplasmic intermediate filament protein in C. elegans.
 Kaminsky R, Denison C, Bening-Abu-Shach U, Chisholm AD, Gygi SP, Broday L.
 Dev Cell. 2009 Nov;17(5):724-35. [PMID: 19922876] 
Functional Description
 Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2. 
Sequence Annotation
 REGION 8 84 Head.
 REGION 85 433 Rod.
 REGION 85 116 Coil 1A.
 REGION 117 130 Linker 1.
 REGION 131 268 Coil 1B.
 REGION 269 285 Linker 12.
 REGION 286 433 Coil 2.
 REGION 434 588 Tail.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Intermediate filament; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 589 AA 
Protein Sequence
MSSHKESSEY EMQYRSTIQP RTAVRSQSRQ SGNYVSGGNG AGSGGRVLKM VTEMGSATVG 60
GISPALSANA AKSFLEATDK EKKTLQGLND RLGNYIDRVK KLEEQNRKLV ADLDELRGKW 120
GKDTSEIKIK YSESLSTARK DIDDAARRKA EVDVKVARHR DDLAEYRSRY EDIQQRRESD 180
REKISQWTNA IADAQSEVEM LRARFKQLTD EEKRVTADNS RIWEELQKAR SDLDDETIGR 240
IDFQNQVQTL MEELEFLRRV HEQEVKELQA LLAQAPADTR EFFKNELALA IRDIKDEYDI 300
IAKQGKQDME SWYKLKVSEV QGSANRANME STYQRDEVKR MRDNIGDLRG KLGDLENKNS 360
LLEKEVQNLN YQLTDDQRQY EAALNDRDAT LRRMREECQT LVAELQALLD TKQMLDAEIA 420
IYRKMLEGEE TRVGLTQMVE QAVKTHSLQQ QENTDSTRSV RGEVSTKTTF QRSAKGNVTI 480
SECDPNGKFI KLENSHRNKD ENVGEHKIRR KLDGRREIVY SIPANVVIKP GKNLTIYARD 540
QGGINNPPES LVFDGENTWG IGANVVTSLV NKDGEERATH TQKTIQSGQ 589 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
 GO:0005198; F:structural molecule activity; IEA:InterPro. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR016451; Intermed_filament_ifa/ifb.
 IPR018039; Intermediate_filament_CS.
 IPR001322; Lamin_tail_dom. 
Pfam
 PF00038; Filament
 PF00932; LTD 
SMART
  
PROSITE
 PS00226; IF 
PRINTS