| Tag | Content |
|---|
| CPLM ID | CPLM-001403 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Coagulation factor V |
Protein Synonyms/Alias | Activated protein C cofactor; Coagulation factor V heavy chain; Coagulation factor V light chain |
Gene Name | F5 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1466 | NNTSLSRKFNPLVVV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. |
Sequence Annotation | DOMAIN 30 328 F5/8 type A 1.
DOMAIN 30 192 Plastocyanin-like 1.
DOMAIN 202 328 Plastocyanin-like 2.
DOMAIN 347 682 F5/8 type A 2.
DOMAIN 347 524 Plastocyanin-like 3.
DOMAIN 534 682 Plastocyanin-like 4.
REPEAT 892 911 1-1.
REPEAT 1175 1183 2-1.
REPEAT 1184 1192 2-2.
REPEAT 1193 1201 2-3.
REPEAT 1202 1210 2-4.
REPEAT 1211 1219 2-5.
REPEAT 1220 1228 2-6.
REPEAT 1229 1237 2-7.
REPEAT 1238 1246 2-8.
REPEAT 1247 1255 2-9.
REPEAT 1256 1264 2-10.
REPEAT 1265 1273 2-11.
REPEAT 1274 1282 2-12.
REPEAT 1283 1291 2-13.
REPEAT 1292 1299 2-14.
REPEAT 1300 1308 2-15.
REPEAT 1309 1316 2-16.
REPEAT 1317 1325 2-17.
REPEAT 1326 1334 2-18.
REPEAT 1335 1341 2-19.
REPEAT 1342 1350 2-20.
REPEAT 1351 1359 2-21.
REPEAT 1360 1368 2-22.
REPEAT 1369 1377 2-23.
REPEAT 1378 1386 2-24.
REPEAT 1387 1395 2-25.
REPEAT 1396 1404 2-26.
REPEAT 1405 1413 2-27.
REPEAT 1414 1422 2-28.
REPEAT 1423 1431 2-29.
REPEAT 1432 1440 2-30.
REPEAT 1441 1449 2-31.
REPEAT 1452 1461 2-32.
DOMAIN 1538 1866 F5/8 type A 3.
DOMAIN 1538 1711 Plastocyanin-like 5.
DOMAIN 1721 1866 Plastocyanin-like 6.
DOMAIN 1866 2020 F5/8 type C 1.
DOMAIN 2025 2180 F5/8 type C 2.
REGION 691 1533 B (By similarity).
REGION 892 908 1 X 17 AA tandem repeats.
REGION 1175 1461 32 X 9 AA approximate tandem repeats of
METAL 138 138 Calcium (By similarity).
METAL 139 139 Calcium (By similarity).
METAL 1802 1802 Copper (By similarity).
METAL 1804 1804 Copper (By similarity).
MOD_RES 638 638 Phosphothreonine (By similarity).
MOD_RES 692 692 Sulfotyrosine (Potential).
MOD_RES 725 725 Sulfotyrosine (Potential).
CARBOHYD 176 176 N-linked (GlcNAc...) (Potential).
CARBOHYD 238 238 N-linked (GlcNAc...) (Potential).
CARBOHYD 381 381 N-linked (GlcNAc...) (Potential).
CARBOHYD 841 841 N-linked (GlcNAc...).
CARBOHYD 959 959 N-linked (GlcNAc...) (Potential).
CARBOHYD 972 972 N-linked (GlcNAc...) (Potential).
CARBOHYD 1438 1438 N-linked (GlcNAc...) (Potential).
CARBOHYD 1811 1811 N-linked (GlcNAc...) (Potential).
DISULFID 1866 2020 By similarity.
DISULFID 2025 2180 By similarity. |
Keyword | Blood coagulation; Calcium; Complete proteome; Copper; Disulfide bond; Glycoprotein; Hemostasis; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal; Sulfation; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2183 AA |
Protein Sequence | MLLVCPCFFL LVVLGTRWAG WGSHQAEAAQ LRQFYVAAQG ILWNYHPEPT DPSLNSIPSF 60
KKIVYREYEQ YFKKEKPRSS NSGLLGPTLY AEVGDVIKVH FRNKADKPLS IHPQGIKYSK 120
FSEGASYADH TFPAERKDDA VAPGEEYTYE WIVSEDSGPT PDDPPCLTHI YYSYENLTQD 180
FNSGLIGPLL ICKKGTLTED GTQKMFDKQH VLLFAVFDES KSRSQSPSLM YTINGFVNKT 240
MPDITVCAHD HVSWHLIGMS SGPELFSIHF NGQVLEQNQH KVSTVTLVSA TSTTANMTMS 300
PEGRWIVSSL IPKHYQAGMQ AYIDIKNCPK KTRSPKTLTR EQRRYMKRWE YFIAAEEVIW 360
NYAPVIPANM DKIYRSQHLD NFSNQIGKHY KKVIYRQYEE ETFTKRTDNP SIKQSGILGP 420
VIRAQVRDTL KIVFKNMASR PYSIYPHGVT FSPYEDGINS SSTSGSHTTI RPVQPGETFT 480
YKWNILEFDE PTENDAQCLT RPYYSDVDVT RDIASGLIGL LLICKSRSLD QRGVQRVADI 540
EQQAVFAVFD ENKSWYIEDN INKFCENPDE VKRDDPKFYE SNIMSTINGY VPESISTLGF 600
CFDDTVQWHF CSVGTHDDIL TIHFTGHSFI YGRRHEDTLT LFPMRGESVT VTMDNVGTWM 660
LTTMNSNPKR RNLRLRFRDV KCNRDYDNED SYEIYEPPAP TSMTTRRIHD SLENEFGIDN 720
EDDDYQYLLA SSLGIRSFKN SSLNPEENEF NLTALALENS SEFISPSTDR VVDSNSSRIL 780
SKIINNNLKD FQRTLPGSGA TVAGTLLRNL IGLDENFVLN SSTEHRSSSY HENDMENPQS 840
NITMVYLLPL GPKGSGNREQ DKPKTIKTGR PHMMKHRFSW MKAPAGKTGR HSNPKNSYSG 900
MKSEEDIPSE LIPLKQKITS KFLNRRWRVA SEKGSYEIIA ANGEDTDVDK LTNSPQNQNI 960
TVPRGESTSH TNTTRKPSDL PTFSGVGHKS PHVRQEEENS GFQKRQLFIR TRKKKKNKKL 1020
ALHSPLSPRG FDPLRGHNHS PFPDRRLLNH SLLLHKSNET ALSPDLNQTS PSMSTDRSLP 1080
DYNQYSKNDT EQMSSSLDLY QSVPAEEHSP TFPAQDPDQT HSTTDPSYRS SPPELSQGLD 1140
YDLSHDFYPD DIGLTSFFPD QSQKSSFSSD DDQAIPSSDL SLFTISPELD QTIIYPDLDQ 1200
LLLSPEDNQK TSSPDLGQVP LSPDDNQKTS SPDLGQVSLS PDDNQKTSSP DLGQVPLSLD 1260
DNQKTTSPDL GQVPLSPDDN QMITSPDLGQ VPLSSDNQKT SSPDLGQVPL FPEDNQNYFL 1320
DLSQVPLSSD QNQETSSTDL LTLSPDFGQT VLSPDLDQLP LPSDNSQVTV SPDLSLLTLS 1380
PDFNEIILAP DLGQVTLSPD LIQTNPALNH GHKASSADPD QASYPPDSGQ ASSLPELNRT 1440
LPHPDLTHIP PPSPSPTLNN TSLSRKFNPL VVVGLSRVDG DDVEIVPSEE PERIDEDYAE 1500
DDFVTYNDPY RTDTRTDVNS SRNPDTIAAW YLRGHGGHKK FYYIAAEEIT WNYAEFAQSE 1560
MDHEDTGHTP KDTTYKKVVF RKYLDSTFTS RDPRAEYEEH LGILGPVIRA EVDDVIQVRF 1620
KNLASRPYSL HAHGLSYEKS SEGKTYEDES PEWFQEDDAV QPNSSYTYVW HATKRSGPEN 1680
PGSACRAWAY YSAVNVERDI HSGLIGPLLI CRKGTLHMER NLPMDMREFV LLFMVFDEKK 1740
SWYYEKSKGS RRIESPEEKN AHKFYAINGM IYNLPGLRMY EQEWVRLHLL NMGGSRDIHV 1800
VHFHGQTLLD NRTKQHQLGV WPLLPGSFKT LEMKASKPGW WLLDTEVGEN QVAGMQTPFL 1860
IIDKECKMPM GLSTGVISDS QIKASEYLTY WEPRLARLNN AGSYNAWSIE KTALDFPIKP 1920
WIQVDMQKEV VVTGIQTQGA KHYLKSCFTT EFQVAYSSDQ TNWQIFRGKS GKSVMYFTGN 1980
SDGSTIKENR LDPPIVARYI RIHPTKSYNR PTLRLELQGC EVNGCSTPLG LEDGRIQDKQ 2040
ITASSFKKSW WGDYWEPSLA RLNAQGRVNA WQAKANNNKQ WLQVDLLKIK KVTAIVTQGC 2100
KSLSSEMYVK SYSIQYSDQG VAWKPYRQKS SMVDKIFEGN SNTKGHMKNF FNPPIISRFI 2160
RIIPKTWNQS IALRLELFGC DIY 2183 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |