CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035023
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aromatic-L-amino-acid decarboxylase 
Protein Synonyms/Alias
 L-Dopa decarboxylase variant 
Gene Name
 Ddc 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
343AYIRKHVKLSHEFESacetylation[1]
403VPCRLRDKFVLRFAVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lyase; Pyridoxal phosphate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 440 AA 
Protein Sequence
MDSREFRRRG KEMVDYIADY LDGIEGRPVY PDVEPGYLRA LIPTTAPQEP ETYEDIIRDI 60
EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC IGFSWGSASE ATLVALLAAR 120
TKMIRQLQAA SPELTQAALM EKLVAYTSDQ AHSSVERAGL IGGVKIKAIP SDGNYSMRAA 180
ALREALERDK AAGLIPFFVV VTLGTTSCCS FDNLLEVGPI CNQEGVWLHI DAAYAGSAFI 240
CPEFRYLLNG VEFADSFNFN PHKWLLVNFD CSAMWVKKRT DLTEAFNMDP VYLRHSHQDS 300
GLITDYRHWQ IPLGRRFRSL KMWFVFRMYG VKGLQAYIRK HVKLSHEFES LVRQDPRFEI 360
CTEVILGLVC FRLKGSNQLN ETLLQRINSA KKIHLVPCRL RDKFVLRFAV CSRTVESAHV 420
QLAWEHIRDL ASSVLRAEKE 440 
Gene Ontology
 GO:0016831; F:carboxy-lyase activity; IEA:InterPro.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro. 
Interpro
 IPR010977; Aromatic_deC.
 IPR002129; PyrdxlP-dep_de-COase.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR021115; Pyridoxal-P_BS. 
Pfam
 PF00282; Pyridoxal_deC 
SMART
  
PROSITE
 PS00392; DDC_GAD_HDC_YDC 
PRINTS
 PR00800; YHDCRBOXLASE.