UniProt Accession

 TI17A_HUMAN; Q99595; B2RDM5; Q9BWF5 

Genbank Protein ID

 X97544; AF106622; AK315602; CH471067; BC000294; BC004439; BC007106; BC009784; BC015098; BC020833 

Genbank Nucleotide ID

 CAA66146.1; AAD19596.1; BAG37972.1; EAW91384.1; AAH00294.2; AAH04439.1; AAH07106.1; AAH09784.1; AAH15098.1; AAH20833.1 

Protein Name

 Mitochondrial import inner membrane translocase subunit Tim17-A 

Protein Synonyms/Alias

 Inner membrane preprotein translocase Tim17a 

Gene Name

 TIMM17A 

Gene Synonyms/Alias

 MIMT17; TIM17; TIM17A; TIMM17 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
56	RGSLTAIKTRAPQLG	ubiquitination	[1]
86	SMVQVRGKEDPWNSI	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. 

Sequence Annotation

  

Keyword

 Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 171 AA 

Protein Sequence

Gene Ontology

 GO:0031305; C:integral to mitochondrial inner membrane; IDA:BHF-UCL.
 GO:0005744; C:mitochondrial inner membrane presequence translocase complex; IDA:BHF-UCL.
 GO:0015450; F:P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0006626; P:protein targeting to mitochondrion; TAS:Reactome. 

Interpro

 IPR005678; Tim17.
 IPR003397; Tim17/Tim22/Tim23/PMP24. 

Pfam

 PF02466; Tim17 

SMART

  

PROSITE

  

PRINTS