UniProt Accession

 FHL1_HUMAN; Q13642; B7Z5T4; B7Z793; O95212; Q13230; Q13645; Q5JXI7; Q5M7Y6; Q6IB30; Q9NZ40; Q9UKZ8; Q9Y630 

Genbank Protein ID

 U60115; U29538; AF110763; AF098518; AF063002; AF220153; AK122708; AK289411; AK299381; AK301642; CR456974; AL078638; AL078638; AL078638; CH471150; CH471150; CH471150; BC010998; BC088369; U60118 

Genbank Nucleotide ID

 AAC52021.1; AAC35421.1; AAD21579.1; AAC72390.1; AAC72886.1; AAF32351.1; BAG53680.1; BAF82100.1; BAH13020.1; BAH13529.1; CAG33255.1; CAC18881.1; CAI41062.1; CAI41055.1; EAW88476.1; EAW88478.1; EAW88479.1; AAH10998.1; AAH88369.1; AAC50795.1 

Protein Name

 Four and a half LIM domains protein 1 

Protein Synonyms/Alias

 FHL-1; Skeletal muscle LIM-protein 1; SLIM; SLIM-1 

Gene Name

 FHL1 

Gene Synonyms/Alias

 SLIM1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
22	QGKKYVQKDGHHCCL	acetylation	[1]
106	PKCKGCFKAIVAGDQ	ubiquitination	[2, 3]
118	GDQNVEYKGTVWHKD	acetylation	[4]
118	GDQNVEYKGTVWHKD	ubiquitination	[2, 3]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 May have an involvement in muscle development or hypertrophy. 

Sequence Annotation

 DOMAIN 40 92 LIM zinc-binding 1.
 DOMAIN 101 153 LIM zinc-binding 2.
 DOMAIN 162 212 LIM zinc-binding 3.
 ZN_FING 7 31 C4-type (Potential).  

Keyword

 3D-structure; Alternative splicing; Cardiomyopathy; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Disease mutation; LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 323 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:BHF-UCL.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007517; P:muscle organ development; NAS:UniProtKB.
 GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
 GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IDA:UniProtKB.
 GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; IDA:UniProtKB.
 GO:0009887; P:organ morphogenesis; NAS:UniProtKB.
 GO:0043268; P:positive regulation of potassium ion transport; IDA:BHF-UCL.
 GO:0003254; P:regulation of membrane depolarization; IDA:BHF-UCL.
 GO:1901016; P:regulation of potassium ion transmembrane transporter activity; IDA:BHF-UCL. 

Interpro

 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS