CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013088
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Spatacsin 
Protein Synonyms/Alias
 Spastic paraplegia 11 protein homolog 
Gene Name
 Spg11 
Gene Synonyms/Alias
 Kiaa1840 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
545VDFFLKSKENLLTPSubiquitination[1]
812AFPRYWIKEQDCFKHubiquitination[1]
828SVLDTFLKYDKKDEFubiquitination[1]
973SLPVQSYKSRAGCDFubiquitination[1]
1109KVDPQLLKVALTPYPubiquitination[1]
1295SLAEKLSKLADGDRAacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
 CARBOHYD 1038 1038 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Glycoprotein; Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2430 AA 
Protein Sequence
MAAQPGPGSA ASPGCAGAME RVLPMLLVRI PAEETAQLGP RAQLHRELEA LGSLTAAGSL 60
QVLSLAPGSR GGSSCCLPGP FRQFLWEESQ NSTSRDRPKL LVAREDYELL VYEFDLRDGR 120
CDAALLHGCC GRTLQKLTED QGVSISFKSL RILSFHNNTS LLLINRCLIL RVVFPGKEPG 180
VPVLDCLSLP LPAQAADMII DAQLCERFLF VLSTVGLIYI FNTMDGTQVA QVDLALLRED 240
SEQLEPASVS SFTSLRVSQD LDVLVLVSSA STAVALNLHL YFRQHPGHLL CEGTLEDLPI 300
EGPPGIDEDD LVNSAHNMKL SKVSFQVDRS WRAQLLSLNE SVRGSEPEVS CCAPWFQSAL 360
RLESLESADH TPTVPTHVFI PGDVPRGRCA FPQKEHVKSS DPGRPWKTMH LSEHEQPTEL 420
TCLSVTGFTA LFTWAVGATS CTIGLWDLET QSMQCFSLSQ KCTPVDIGGD QQLCLALTDD 480
GLSLILFGLT QEEFLNRLMI HGSASTVDSL CHLNGWGRCS IPIHALEAGI ENRQLDTVDF 540
FLKSKENLLT PSSQSPAPDQ QHPFSSHLYL RQVEEMSPAL DLLCSAIRES DSETQSKHFA 600
EQLLHLTLSF LNKQIRELCV HTEELDEHFQ KGVAILTSYI NELRTFMIKF PWKPGDAIDE 660
SDVNEGVVTV KEDRVWEELS FEEVIADAIL NNRIPEAQTF FRISGHSAQR LEELVRIGLD 720
LAFDSLKKNN VEEASRLLRN MGFSVEDELL KICFYTTDKN IRDFLVEILK EKECFSEKER 780
RTVDFVHQLE ALYSGHFQEN AQTQAFPRYW IKEQDCFKHK SVLDTFLKYD KKDEFHKQDH 840
RIALNWAHRW DLQTQECILL RRLSPEEYKA RSPEALWRHL TARHDCSSIS LWMEEFQTQE 900
TESPQQSKWP PLSADIIEQG TCCHSHMRNE ILDKLARSGI FLASELEDFE RLLLRLSRIG 960
GVMQDSLPVQ SYKSRAGCDF HSRFILYCLE HGLQHLLYTY LDYYKLSPGN CPFLEKKELH 1020
EAHPWLEFLV QCRQVSSNLT DPKLIFQASL ANAQILIPTN QASVSSMLLE GHTLLALATT 1080
MYAPGGVSQV IQNEDSENCL KKVDPQLLKV ALTPYPKLKA ALFPQYTAPS ILPSDITLYH 1140
LIQSLPPFDP SRLFVWQSAN TLAIGDTGSQ LPHFSSPDLV SKYAVLERLN YAYYLHHGRP 1200
SFAFGTFLVQ ELIKSKTPKQ LIQQVGKEAY TLGLSSFTNP SVGAACVCFL ELLGLSSLKL 1260
RVDLKMANVI LGSKRRDEDA RSSFIRESLA EKLSKLADGD RAATEELLVL LEEGVWDSIE 1320
QQGFSRLSSE SSSQWALVLQ FCMLHDRKLS VSYLRECAKA NDWLQFLVHS QLHNYHPAEV 1380
ESLLQYFSPV LQSHLKLASE KLSSGSISRD DSCLQELQKN KGETSNFFEI LHRCSDESTS 1440
WSWLLAEAVR HRAPILSVLA SCVQGASVVS CLCVWIVTSV EDKVAAEAMG HIQISVEDHH 1500
WSLKDLSIIW RTVLTRRKSH TLIRGFQLFI KDSPLLLIME MYELCMFFKN YEKAKVKLLE 1560
FQKSLETLDT VAARVLPIIP ASWMKDQVCF LLKLMPQQCE TQYELGKLLQ LFVGTEQLFS 1620
DGPDVQKLCL LSQVLKDTPI AISPAVISSY STENFQRECR SILEKLKADG QFAVARRVAE 1680
LAALPVDSLL IEQLTQEMQT LTHTPQWSLK QERLGFWKKC HEIFKKNSIS KRAASSFFSS 1740
QAPEVSEHPA EQGSLEERHL LLTLAGHWLA QEEPVPVEEL EGLEKQIWIC RVAQHTCGGA 1800
EEEAKPSLSQ HKLAAAELSF DSLASELSFS KLAALNTSKY LGLNDLPSKT TCENRLKHKE 1860
QESLNTLIGQ LLDGGCVHEA SRVCQYFRFY SQDLVLVLHC RALASAEATM EDLHSEIRAL 1920
LSSAAQPEDL ESPSVPLRKA HSSSSLDSQS FVMVPPTDEV AQNLHTLISK CLHGKNYCRQ 1980
VLCLYELAKD LGCSYGDVAA RDSEAMLRAI LASQRPDRCR QAQVFINTQG LEADTVAELV 2040
AEEVTRELLT PSEGTGEKQP FNPAEESQTF LQLTALCQDR TLVGMKLLDK IPSVPHGELS 2100
CTTELLILAH HCFTFTCHME GITRVLQAAR MLTDNHLAPN EEYGLVVRLL TGIGRYNEMT 2160
YIFDLLHQKH YFEVLMRKKL DPTGTLKTAL LDYIKRCRPG DSEKHNMIAL CFSMCREIGE 2220
NHEAAACIQL KLIESQPWEE SLKDGAQLKQ LLLKALTLML DAAESYAKDS CVRQALHCNR 2280
LTKLITLQIH FLNSGQNTML INLGHQKLMD CIMTLPRFYQ ASIVAEAYDF VPDWAEVLYQ 2340
QVILKGDFSY LEEFKQQKLL RPNIFEDISK KYKQHQPTDR VTENLKKLLS YCEDIYLYYK 2400
LAYEHKFFEI VNMLLKDPQT GCCLKDMLAG 2430 
Gene Ontology
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS