UniProt Accession

 ASCL1_MOUSE; Q02067; Q7TNT5 

Genbank Protein ID

 M95603; AK143210; AC122360; CH466539; BC055748 

Genbank Nucleotide ID

 AAA37780.1; BAE25307.1; EDL21455.1; AAH55748.1 

Protein Name

 Achaete-scute homolog 1 

Protein Synonyms/Alias

 ASH-1; mASH-1; mASH1 

Gene Name

 Ascl1 

Gene Synonyms/Alias

 Ash1; Mash-1; Mash1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
151	AANKKMSKVETLRSA	acetylation	[1]

Reference

 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 

Functional Description

 Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5'-CANNTG-3'). 

Sequence Annotation

 DOMAIN 113 165 bHLH.  

Keyword

 Activator; Complete proteome; Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 231 AA 

Protein Sequence

Gene Ontology

 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0070888; F:E-box binding; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0000989; F:transcription factor binding transcription factor activity; IDA:UniProtKB.
 GO:0061104; P:adrenal chromaffin cell differentiation; IMP:MGI.
 GO:0061103; P:carotid body glomus cell differentiation; IMP:MGI.
 GO:0071259; P:cellular response to magnetism; IEA:Compara.
 GO:0021954; P:central nervous system neuron development; IMP:MGI.
 GO:0021987; P:cerebral cortex development; IMP:MGI.
 GO:0021892; P:cerebral cortex GABAergic interneuron differentiation; IEA:Compara.
 GO:0048484; P:enteric nervous system development; TAS:BHF-UCL.
 GO:0021879; P:forebrain neuron differentiation; IEA:Compara.
 GO:0061100; P:lung neuroendocrine cell differentiation; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0045665; P:negative regulation of neuron differentiation; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0007400; P:neuroblast fate determination; IMP:MGI.
 GO:0007405; P:neuroblast proliferation; IGI:MGI.
 GO:0048665; P:neuron fate specification; IMP:MGI.
 GO:0001764; P:neuron migration; IMP:MGI.
 GO:0003359; P:noradrenergic neuron fate commitment; IEA:Compara.
 GO:0007219; P:Notch signaling pathway; IGI:MGI.
 GO:0060166; P:olfactory pit development; IMP:MGI.
 GO:0014003; P:oligodendrocyte development; IMP:MGI.
 GO:0048486; P:parasympathetic nervous system development; TAS:BHF-UCL.
 GO:0007389; P:pattern specification process; IMP:MGI.
 GO:0045787; P:positive regulation of cell cycle; IDA:MGI.
 GO:2000179; P:positive regulation of neural precursor cell proliferation; IMP:MGI.
 GO:0050769; P:positive regulation of neurogenesis; IMP:MGI.
 GO:0043525; P:positive regulation of neuron apoptotic process; IMP:MGI.
 GO:0045666; P:positive regulation of neuron differentiation; IDA:UniProtKB.
 GO:0045747; P:positive regulation of Notch signaling pathway; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0060165; P:regulation of timing of subpallium neuron differentiation; IMP:MGI.
 GO:0070849; P:response to epidermal growth factor stimulus; IEA:Compara.
 GO:0051593; P:response to folic acid; IEA:Compara.
 GO:0010226; P:response to lithium ion; IEA:Compara.
 GO:0032526; P:response to retinoic acid; IEA:Compara.
 GO:0021527; P:spinal cord association neuron differentiation; IMP:MGI.
 GO:0021530; P:spinal cord oligodendrocyte cell fate specification; IMP:MGI.
 GO:0061102; P:stomach neuroendocrine cell differentiation; IMP:MGI.
 GO:0060163; P:subpallium neuron fate commitment; IMP:MGI.
 GO:0048485; P:sympathetic nervous system development; TAS:BHF-UCL.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0021750; P:vestibular nucleus development; IMP:MGI. 

Interpro

 IPR015660; ASH.
 IPR011598; bHLH_dom. 

Pfam

 PF00010; HLH 

SMART

 SM00353; HLH 

PROSITE

 PS50888; BHLH 

PRINTS