UniProt Accession

 1433E_RAT; P62260; P29360; P42655; Q63631 

Genbank Protein ID

 M84416; D30739; U53882; BC063163 

Genbank Nucleotide ID

 AAC37659.1; BAA06401.1; AAC52676.1; AAH63163.1 

Protein Name

 14-3-3 protein epsilon 

Protein Synonyms/Alias

 14-3-3E; Mitochondrial import stimulation factor L subunit; MSF L 

Gene Name

 Ywhae 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
12	EDLVYQAKLAEQAER	acetylation	[1]
28	DEMVESMKKVAGMDV	acetylation	[1]
50	NLLSVAYKNVIGARR	acetylation	[1]
69	IISSIEQKEENKGGE	acetylation	[1]
69	IISSIEQKEENKGGE	ubiquitination	[2]
73	IEQKEENKGGEDKLK	acetylation	[1]
78	ENKGGEDKLKMIREY	acetylation	[1]
118	AANTGESKVFYYKMK	acetylation	[1]
118	AANTGESKVFYYKMK	ubiquitination	[2]
123	ESKVFYYKMKGDYHR	acetylation	[1]
125	KVFYYKMKGDYHRYL	acetylation	[1]
125	KVFYYKMKGDYHRYL	ubiquitination	[2]
142	FATGNDRKEAAENSL	acetylation	[1]
142	FATGNDRKEAAENSL	ubiquitination	[2]
244	GDGEEQNKEALQDVE	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 50 50 N6-acetyllysine (By similarity).
 MOD_RES 69 69 N6-acetyllysine (By similarity).
 MOD_RES 118 118 N6-acetyllysine (By similarity).
 MOD_RES 123 123 N6-acetyllysine (By similarity).
 MOD_RES 210 210 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 255 AA 

Protein Sequence

Gene Ontology

 GO:0005871; C:kinesin complex; IDA:RGD.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0008426; F:protein kinase C inhibitor activity; TAS:RGD.
 GO:0021987; P:cerebral cortex development; IEA:Compara.
 GO:0021766; P:hippocampus development; IEA:Compara.
 GO:0035308; P:negative regulation of protein dephosphorylation; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0006605; P:protein targeting; IEA:Compara.
 GO:0007165; P:signal transduction; TAS:RGD. 

Interpro

 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 

Pfam

 PF00244; 14-3-3 

SMART

 SM00101; 14_3_3 

PROSITE

 PS00796; 1433_1
 PS00797; 1433_2 

PRINTS

 PR00305; 1433ZETA.