CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015227
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Anoctamin-6 
Protein Synonyms/Alias
 Small-conductance calcium-activated nonselective cation channel; SCAN channel; Transmembrane protein 16F 
Gene Name
 Ano6 
Gene Synonyms/Alias
 Tmem16f 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
58EFEEFNGKPDSLFFTubiquitination[1]
177RVNESVIKPEQEFFTubiquitination[1]
889SHLKDLTKNMGIIAEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. 
Sequence Annotation
 CARBOHYD 330 330 N-linked (GlcNAc...) (Potential).
 CARBOHYD 362 362 N-linked (GlcNAc...) (Potential).
 CARBOHYD 492 492 N-linked (GlcNAc...); atypical.
 CARBOHYD 494 494 N-linked (GlcNAc...).
 CARBOHYD 778 778 N-linked (GlcNAc...) (Potential).
 CARBOHYD 785 785 N-linked (GlcNAc...).
 CARBOHYD 803 803 N-linked (GlcNAc...).  
Keyword
 Alternative splicing; Cell membrane; Chloride; Chloride channel; Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 911 AA 
Protein Sequence
MQMMTRKVLL NMELEEDDDE DGDIVLENFD QTIVCPTFGS LENQQDFRTP EFEEFNGKPD 60
SLFFTDGQRR IDFILVYEDE SKKENNKKGT NEKQKRKRQA YESNLICHGL QLEATRSVSD 120
DKLVFVKVHA PWEVLCTYAE IMHIKLPLKP NDLKTRSPFG NLNWFTKVLR VNESVIKPEQ 180
EFFTAPFEKS RMNDFYILDR DSFFNPATRS RIVYFILSRV KYQVMNNVNK FGINRLVSSG 240
IYKAAFPLHD CRFNYESEDI SCPSERYLLY REWAHPRSIY KKQPLDLIRK YYGEKIGIYF 300
AWLGYYTQML LLAAVVGVAC FLYGYLDQDN CTWSKEVCDP DIGGQILMCP QCDRLCPFWR 360
LNITCESSKK LCIFDSFGTL IFAVFMGVWV TLFLEFWKRR QAELEYEWDT VELQQEEQAR 420
PEYEAQCNHV VINEITQEEE RIPFTTCGKC IRVTLCASAV FFWILLIIAS VIGIIVYRLS 480
VFIVFSTTLP KNPNGTDPIQ KYLTPQMATS ITASIISFII IMILNTIYEK VAIMITNFEL 540
PRTQTDYENS LTMKMFLFQF VNYYSSCFYI AFFKGKFVGY PGDPVYLLGK YRSEECDPGG 600
CLLELTTQLT IIMGGKAIWN NIQEVLLPWV MNLIGRYKRV SGSEKITPRW EQDYHLQPMG 660
KLGLFYEYLE MIIQFGFVTL FVASFPLAPL LALVNNILEI RVDAWKLTTQ FRRMVPEKAQ 720
DIGAWQPIMQ GIAILAVVTN AMIIAFTSDM IPRLVYYWSF SIPPYGDHTY YTMDGYINNT 780
LSVFNITDFK NTDKENPYIG LGNYTLCRYR DFRNPPGHPQ EYKHNIYYWH VIAAKLAFII 840
VMEHIIYSVK FFISYAIPDV SKITKSKIKR EKYLTQKLLH ESHLKDLTKN MGIIAERIGG 900
TVDNSVRPKL E 911 
Gene Ontology
 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0005622; C:intracellular; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005227; F:calcium activated cation channel activity; IDA:UniProtKB.
 GO:0005254; F:chloride channel activity; IDA:MGI.
 GO:0005244; F:voltage-gated ion channel activity; IDA:UniProtKB.
 GO:0002543; P:activation of blood coagulation via clotting cascade; IEA:Compara.
 GO:0007596; P:blood coagulation; IMP:UniProtKB.
 GO:0097045; P:phosphatidylserine exposure on blood platelet; IEA:Compara.
 GO:0017121; P:phospholipid scrambling; IMP:UniProtKB. 
Interpro
 IPR007632; Anoctamin. 
Pfam
 PF04547; Anoctamin 
SMART
  
PROSITE
  
PRINTS