CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021745
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Delta-like protein 4 
Protein Synonyms/Alias
 Drosophila Delta homolog 4; Delta4 
Gene Name
 Dll4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
577NNLSDFQKDNLIPAAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. 
Sequence Annotation
 DOMAIN 174 218 DSL.
 DOMAIN 219 252 EGF-like 1.
 DOMAIN 253 283 EGF-like 2.
 DOMAIN 285 323 EGF-like 3.
 DOMAIN 325 361 EGF-like 4.
 DOMAIN 364 401 EGF-like 5.
 DOMAIN 403 439 EGF-like 6.
 DOMAIN 441 477 EGF-like 7.
 DOMAIN 481 519 EGF-like 8.
 CARBOHYD 79 79 N-linked (GlcNAc...) (Potential).
 CARBOHYD 109 109 N-linked (GlcNAc...) (Potential).
 CARBOHYD 162 162 N-linked (GlcNAc...) (Potential).
 CARBOHYD 297 297 N-linked (GlcNAc...) (Potential).
 CARBOHYD 394 394 N-linked (GlcNAc...) (Potential).
 DISULFID 176 185 By similarity.
 DISULFID 189 201 By similarity.
 DISULFID 209 218 By similarity.
 DISULFID 223 234 By similarity.
 DISULFID 227 240 By similarity.
 DISULFID 242 251 By similarity.
 DISULFID 254 265 By similarity.
 DISULFID 260 271 By similarity.
 DISULFID 273 282 By similarity.
 DISULFID 289 301 By similarity.
 DISULFID 295 311 By similarity.
 DISULFID 313 322 By similarity.
 DISULFID 329 340 By similarity.
 DISULFID 334 349 By similarity.
 DISULFID 351 360 By similarity.
 DISULFID 367 378 By similarity.
 DISULFID 372 389 By similarity.
 DISULFID 391 400 By similarity.
 DISULFID 407 418 By similarity.
 DISULFID 412 427 By similarity.
 DISULFID 429 438 By similarity.
 DISULFID 445 456 By similarity.
 DISULFID 450 465 By similarity.
 DISULFID 467 476 By similarity.
 DISULFID 485 496 By similarity.
 DISULFID 490 507 By similarity.
 DISULFID 509 518 By similarity.  
Keyword
 Angiogenesis; Complete proteome; Developmental protein; Differentiation; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Notch signaling pathway; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 686 AA 
Protein Sequence
MTPASRSACR WALLLLAVLW PQQRAAGSGI FQLRLQEFVN QRGMLANGQS CEPGCRTFFR 60
ICLKHFQATF SEGPCTFGNV STPVLGTNSF VVRDKNSGSG RNPLQLPFNF TWPGTFSLNI 120
QAWHTPGDDL RPETSPGNSL ISQIIIQGSL AVGKIWRTDE QNDTLTRLSY SYRVICSDNY 180
YGESCSRLCK KRDDHFGHYE CQPDGSLSCL PGWTGKYCDQ PICLSGCHEQ NGYCSKPDEC 240
ICRPGWQGRL CNECIPHNGC RHGTCSIPWQ CACDEGWGGL FCDQDLNYCT HHSPCKNGST 300
CSNSGPKGYT CTCLPGYTGE HCELGLSKCA SNPCRNGGSC KDQENSYHCL CPPGYYGQHC 360
EHSTLTCADS PCFNGGSCRE RNQGSSYACE CPPNFTGSNC EKKVDRCTSN PCANGGQCQN 420
RGPSRTCRCR PGFTGTHCEL HISDCARSPC AHGGTCHDLE NGPVCTCPAG FSGRRCEVRI 480
THDACASGPC FNGATCYTGL SPNNFVCNCP YGFVGSRCEF PVGLPPSFPW VAVSLGVGLV 540
VLLVLLVMVV VAVRQLRLRR PDDESREAMN NLSDFQKDNL IPAAQLKNTN QKKELEVDCG 600
LDKSNCGKLQ NHTLDYNLAP GLLGRGGMPG KYPHSDKSLG EKVPLRLHSE KPECRISAIC 660
SPRDSMYQSV CLISEERNEC VIATEV 686 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; ISS:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005112; F:Notch binding; IDA:MGI.
 GO:0072554; P:blood vessel lumenization; IMP:BHF-UCL.
 GO:0001974; P:blood vessel remodeling; IMP:BHF-UCL.
 GO:0003209; P:cardiac atrium morphogenesis; IMP:BHF-UCL.
 GO:0044344; P:cellular response to fibroblast growth factor stimulus; ISS:UniProtKB.
 GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; ISS:UniProtKB.
 GO:0035912; P:dorsal aorta morphogenesis; IMP:BHF-UCL.
 GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; ISS:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0061314; P:Notch signaling involved in heart development; IMP:BHF-UCL.
 GO:0001569; P:patterning of blood vessels; IMP:BHF-UCL.
 GO:0003344; P:pericardium morphogenesis; IMP:BHF-UCL.
 GO:0050767; P:regulation of neurogenesis; IMP:MGI.
 GO:0003222; P:ventricular trabecula myocardium morphogenesis; IMP:BHF-UCL. 
Interpro
 IPR001774; DSL.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR011651; Notch_ligand_N. 
Pfam
 PF01414; DSL
 PF00008; EGF
 PF12661; hEGF
 PF07657; MNNL 
SMART
 SM00051; DSL
 SM00181; EGF
 SM00179; EGF_CA 
PROSITE
 PS00010; ASX_HYDROXYL
 PS51051; DSL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3 
PRINTS