UniProt Accession

 PSAL_HUMAN; A6NEC2; A8MZ60 

Genbank Protein ID

 AK125832; AC021317; BC067792 

Genbank Nucleotide ID

  

Protein Name

 Puromycin-sensitive aminopeptidase-like protein 

Protein Synonyms/Alias

  

Gene Name

 NPEPPSL1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
19	DENLVEVKFARTPVT	ubiquitination	[1]
78	AKTLPFYKDYFNVPY	ubiquitination	[1]
225	FDAISYSKGASVIRM	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Aminopeptidase with broad substrate specificity to several peptides (By similarity). 

Sequence Annotation

 REGION 316 320 Substrate binding (By similarity).
 ACT_SITE 353 353 Proton acceptor (By similarity).
 METAL 352 352 Zinc; catalytic (By similarity).
 METAL 356 356 Zinc; catalytic (By similarity).
 METAL 375 375 Zinc; catalytic (By similarity).
 BINDING 180 180 Substrate (By similarity).  

Keyword

 Alternative splicing; Aminopeptidase; Complete proteome; Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 478 AA 

Protein Sequence

Gene Ontology

 GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
 GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR001930; Peptidase_M1.
 IPR014782; Peptidase_M1_N.
 IPR015568; Peptidase_M1_puromycin-sens. 

Pfam

 PF01433; Peptidase_M1 

SMART

  

PROSITE

 PS00142; ZINC_PROTEASE 

PRINTS

 PR00756; ALADIPTASE.