CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022072
UniProt Accession
Genbank Protein ID
 AF222983; AF222987; AF222980; AJ506178; AJ506177; AB007926; FJ804174; FJ804178; FJ804180; FJ804182; FJ804184; FJ804186; FJ804190; FJ804191; FJ804196; FJ804197; FJ804199; FJ804200; FJ804203; FJ804204; FJ804205; FJ804208; FJ804212; AL626763; AL136171; AL161743; AL359543; AL445200; AL450284; AL626763; AL136171; AL359543; AL450284; AL626763; AL359543; AL450284; AL136171; AL161743; AL359543; AL445200; AL626763; AL450284; AL136171; AL359543; AL626763; AL359543; AL136171; AL161743; AL445200; AL450284; AL626763; AL359543; AL136171; AL450284; AL626763; AL359543; AL626763; AL136171; AL161743; AL359543; AL445200; AL450284; AL626763; AL136171; AL359543; AL450284; AL626763; AL161743; AL136171; AL359543; AL445200; AL450284; AL626763; AL445200; AL136171; AL161743; AL359543; AL450284; AL626763; AL751364 
Genbank Nucleotide ID
 AAF73874.1; AAF73877.1; AAF73889.1; CAD44628.1; CAD44631.1; BAA32302.1; ACR40040.1; ACR40044.1; ACR40046.1; ACR40048.1; ACR40050.1; ACR40052.1; ACR40056.1; ACR40057.1; ACR40062.1; ACR40063.1; ACR40065.1; ACR40066.1; ACR40069.1; ACR40070.1; ACR40071.1; ACR40074.1; ACR40078.1; CAH70955.1; CAH70955.1; CAH70955.1; CAH70955.1; CAH70955.1; CAH70955.1; CAH70956.1; CAH70956.1; CAH70956.1; CAH70956.1; CAH70957.1; CAH70957.1; CAI15677.1; CAI15677.1; CAI15677.1; CAI15677.1; CAI15677.1; CAI15677.1; CAI15679.1; CAI15679.1; CAI15679.1; CAI15679.1; CAI17204.1; CAI17204.1; CAI17204.1; CAI17204.1; CAI17204.1; CAI17204.1; CAI17206.1; CAI17206.1; CAI17206.1; CAI17206.1; CAI17207.1; CAI17207.1; CAI21886.1; CAI21886.1; CAI21886.1; CAI21886.1; CAI21886.1; CAI21886.1; CAI21888.1; CAI21888.1; CAI21888.1; CAI21888.1; CAI22543.1; CAI22543.1; CAI22543.1; CAI22543.1; CAI22543.1; CAI22543.1; CAI23013.1; CAI23013.1; CAI23013.1; CAI23013.1; CAI23013.1; CAI23013.1 
Protein Name
 Disrupted in schizophrenia 1 protein 
Protein Synonyms/Alias
  
Gene Name
 DISC1 
Gene Synonyms/Alias
 KIAA0457 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
332SWDTLLRKWEPVLRDubiquitination[1]
372VENDDYDKAETLQQRubiquitination[1]
387LEDLEQEKISLHFQLubiquitination[1]
462RDWLLQEKQQLQKEIubiquitination[1]
467QEKQQLQKEIEALQAubiquitination[1]
551RSLQERIKSLNLSLKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. 
Sequence Annotation
 REGION 1 292 Interaction with MAP1A.
 REGION 293 696 Interaction with TRAF3IP1.
 REGION 440 597 Required for localization to punctate
 REGION 446 854 Necessary and sufficient for interaction
 REGION 598 854 Interaction with ATF4 and ATF5.
 REGION 727 854 Interaction with PAFAH1B1.
 REGION 802 835 Interaction with NDEL1.  
Keyword
 Alternative splicing; Cell junction; Cell membrane; Chromosomal rearrangement; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Membrane; Microtubule; Neurogenesis; Polymorphism; Postsynaptic cell membrane; Reference proteome; Schizophrenia; Synapse; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 854 AA 
Protein Sequence
MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA 60
VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI 120
QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA 180
ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ 240
SPQEMGAKAA SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG 300
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL 360
QEDAVENDDY DKAETLQQRL EDLEQEKISL HFQLPSRQPA LSSFLGHLAA QVQAALRRGA 420
TQQASGDDTH TPLRMEPRLL EPTAQDSLHV SITRRDWLLQ EKQQLQKEIE ALQARMFVLE 480
AKDQQLRREI EEQEQQLQWQ GCDLTPLVGQ LSLGQLQEVS KALQDTLASA GQIPFHAEPP 540
ETIRSLQERI KSLNLSLKEI TTKVCMSEKF CSTLRKKVND IETQLPALLE AKMHAISGNH 600
FWTAKDLTEE IRSLTSEREG LEGLLSKLLV LSSRNVKKLG SVKEDYNRLR REVEHQETAY 660
ETSVKENTMK YMETLKNKLC SCKCPLLGKV WEADLEACRL LIQSLQLQEA RGSLSVEDER 720
QMDDLEGAAP PIPPRLHSED KRKTPLKVLE EWKTHLIPSL HCAGGEQKEE SYILSAELGE 780
KCEDIGKKLL YLEDQLHTAI HSHDEDLIQS LRRELQMVKE TLQAMILQLQ PAKEAGEREA 840
AASCMTAGVH EAQA 854 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0021846; P:cell proliferation in forebrain; IEA:Compara.
 GO:0021799; P:cerebral cortex radially oriented cell migration; IEA:Compara.
 GO:0000226; P:microtubule cytoskeleton organization; IMP:UniProtKB.
 GO:0051560; P:mitochondrial calcium ion homeostasis; IEA:Compara.
 GO:0001764; P:neuron migration; IMP:UniProtKB.
 GO:0002052; P:positive regulation of neuroblast proliferation; IGI:UniProtKB.
 GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:0030177; P:positive regulation of Wnt receptor signaling pathway; IGI:UniProtKB.
 GO:0010975; P:regulation of neuron projection development; IEA:Compara.
 GO:0090128; P:regulation of synapse maturation; IEA:Compara.
 GO:0031929; P:TOR signaling cascade; IEA:Compara. 
Interpro
 IPR026081; DISC1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS