UniProt Accession

 PCY1A_HUMAN; P49585; A9LYK9; D3DXB1; Q86Y88 

Genbank Protein ID

 L28957; EU280320; CH471191; CH471191; BC046355 

Genbank Nucleotide ID

 AAA72127.1; ABX44666.1; EAW53655.1; EAW53662.1; AAH46355.1 

Protein Name

 Choline-phosphate cytidylyltransferase A 

Protein Synonyms/Alias

 CCT-alpha; CTP:phosphocholine cytidylyltransferase A; CCT A; CT A; Phosphorylcholine transferase A 

Gene Name

 PCYT1A 

Gene Synonyms/Alias

 CTPCT; PCYT1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MDAQCSAKVNARKRR	acetylation	[1]
33	EEDGVPSKVQRCAVG	ubiquitination	[2, 3]
57	EIEVDFSKPYVRVTM	ubiquitination	[2]
183	AGSDDVYKHIKEAGM	ubiquitination	[2]
186	DDVYKHIKEAGMFAP	ubiquitination	[2, 3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Controls phosphatidylcholine synthesis. 

Sequence Annotation

 REPEAT 319 324 1.
 REPEAT 329 333 2; approximate.
 REPEAT 343 348 3.
 NP_BIND 84 92 CTP (By similarity).
 NP_BIND 168 169 CTP (By similarity).
 NP_BIND 196 200 CTP (By similarity).
 REGION 228 287 Amphipathic (Potential).
 REGION 256 288 3 X 11 AA approximate tandem repeats.
 REGION 319 348 3 X repeats.
 BINDING 122 122 CTP (By similarity).
 BINDING 122 122 Substrate (By similarity).
 BINDING 151 151 Substrate (By similarity).
 BINDING 173 173 CTP (By similarity).
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 8 8 N6-acetyllysine.
 MOD_RES 315 315 Phosphoserine.
 MOD_RES 319 319 Phosphoserine.
 MOD_RES 321 321 Phosphoserine (By similarity).
 MOD_RES 322 322 Phosphoserine (By similarity).
 MOD_RES 323 323 Phosphoserine (By similarity).
 MOD_RES 329 329 Phosphoserine (By similarity).
 MOD_RES 331 331 Phosphoserine (By similarity).
 MOD_RES 333 333 Phosphoserine (By similarity).
 MOD_RES 343 343 Phosphoserine.
 MOD_RES 347 347 Phosphoserine.
 MOD_RES 352 352 Phosphoserine.
 MOD_RES 362 362 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Lipid biosynthesis; Lipid metabolism; Membrane; Nucleotidyltransferase; Phospholipid biosynthesis; Phospholipid metabolism; Phosphoprotein; Reference proteome; Repeat; Transferase; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 367 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0042587; C:glycogen granule; ISS:UniProtKB.
 GO:0004105; F:choline-phosphate cytidylyltransferase activity; ISS:UniProtKB.
 GO:0008289; F:lipid binding; IEA:Compara.
 GO:0009628; P:response to abiotic stimulus; IEA:Compara. 

Interpro

 IPR004821; Cyt_trans-like.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF01467; CTP_transf_2 

SMART

  

PROSITE

  

PRINTS