CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015775
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DET1 homolog 
Protein Synonyms/Alias
 De-etiolated-1 homolog 
Gene Name
 DET1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
426RQIQRRFKDTIINAKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Nucleus; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 550 AA 
Protein Sequence
MDHHVSTIKP RRIQNQNVIH RLERRRISSG KAGTHWHQVR VFHQNVFPNF TVVNVEKPPC 60
FLRKFSPDGR YFIAFSSDQT SLEIYEYQGC QAAEDLLQGY EGEILSNGND QRSVNIRGRL 120
FERFFVLLHI TNVAANGEHL NRECSLFTDD CRCVIVGSAA YLPDEPHPPF FEVYRNSESV 180
TPNPRSPLED YSLHIIDLHT GRLCDTRTFK CDKVVLSHNQ GLYLYKNILA ILSVQQQTIH 240
VFQVTPEGTF IDVRTIGRFC YEDDLLTVSA VFPEVQRDSQ TGMANPFRDP FINSLKHRLL 300
VYLWRRAEQD GSAMAKRRFF QYFDQLRQLR MWKMQLLDEN HLFIKYTSED VVTLRVTDPS 360
QASFFVVYNM VTTEVIAVFE NTSDELLELF ENFCDLFRNA TLHSEVQFPC SASSNNFARQ 420
IQRRFKDTII NAKYGGHTEA VRRLLGQLPI SAQSYSGSPY LDLSLFSYDD KWVSVMERPK 480
TCGDHPIRFY ARDSGLLKFE IQAGLLGRPI NHTVRRLVAF TFHPFEPFAI SVQRTNAEYV 540
VNFHMRHCCT 550 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR019138; De-etiolated_protein_1_Det1. 
Pfam
 PF09737; Det1 
SMART
  
PROSITE
  
PRINTS