CPLM-023638

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-023638

UniProt Accession

AKAP2_HUMAN; Q9Y2D5; B1ALX9; B2RTU4; B3KQ00; B4DTZ2; B7ZW07; B9EJB5; Q9UG26

Genbank Protein ID

AJ303079; AB023137; AK057098; AK300427; AL627225; AL158823; AL158829; AL353598; AL353806; AL353806; AL158823; AL158829; AL353598; AL627225; AL158829; AL158823; AL353598; AL353806; AL627225; AL158823; AL158829; AL353598; AL353806; AL627225; AL353598; AL158823; AL158829; AL353806; AL627225; CH471105; BC140818; BC146863; BC171800; AL110268

Genbank Nucleotide ID

CAC38839.1; BAA76764.2; BAG51862.1; BAG62154.1; CAI10811.1; CAI10811.1; CAI10811.1; CAI10811.1; CAI10811.1; CAI12434.1; CAI12434.1; CAI12434.1; CAI12434.1; CAI12434.1; CAI13896.1; CAI13896.1; CAI13896.1; CAI13896.1; CAI13896.1; CAI39560.1; CAI39560.1; CAI39560.1; CAI39560.1; CAI39560.1; CAI40816.1; CAI40816.1; CAI40816.1; CAI40816.1; CAI40816.1; EAW59057.1; AAI40819.1; AAI46864.1; AAI71800.1; CAB53707.1

Protein Name

A-kinase anchor protein 2

Protein Synonyms/Alias

AKAP-2; AKAP-KL; Protein kinase A-anchoring protein 2; PRKA2

Gene Name

AKAP2

Gene Synonyms/Alias

KIAA0920; PRKA2

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
429	SKRGPLSKLWAEDGE	ubiquitination	[1]
448	RAVLTVVKDDDHGIL	ubiquitination	[1]
710	DVMVGPFKLRSRKQR	ubiquitination	[1]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity).

Sequence Annotation

REGION 566 579 PKA-RII subunit binding domain.
MOD_RES 121 121 Phosphoserine.
MOD_RES 152 152 Phosphoserine.
MOD_RES 336 336 Phosphoserine (By similarity).
MOD_RES 393 393 Phosphoserine.
MOD_RES 461 461 Phosphoserine.
MOD_RES 631 631 Phosphoserine.
MOD_RES 720 720 Phosphoserine.
MOD_RES 748 748 Phosphoserine.
MOD_RES 778 778 Phosphoserine (By similarity).

Keyword

Alternative splicing; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

859 AA

Protein Sequence

MEIEVSVAEC KSVPGITSTP HPMDHPSAFY SPPHNGLLTD HHESLDNDVA REIRYLDEVL 60
EANCCDSAVD GTYNGTSSPE PGAVVLVGGL SPPVHEATQP EPTERTASRQ APPHIELSNS 120
SPDPMAEAER TNGHSPSQPR DALGDSLQVP VSPSSTTSSR CSSRDGEFTL TTLKKEAKFE 180
LRAFHEDKKP SKLFEDDEHE KEQYCIRKVR PSEEMLELEK ERRELIRSQA VKKNPGIAAK 240
WWNPPQEKTI EEQLDEEHLE SHKKYKERKE RRAQQEQLLL QKQLQQQQQQ PPSQLCTAPA 300
SSHERASMID KAKEDIVTEQ IDFSAARKQF QLMENSRQAV AKGQSTPRLF SIKPFYRPLG 360
SVNSDKPLTN PRPPSVGGPP EDSGASAAKG QKSPGALETP SAAGSQGNTA SQGKEGPYSE 420
PSKRGPLSKL WAEDGEFTSA RAVLTVVKDD DHGILDQFSR SVNVSLTQEE LDSGLDELSV 480
RSQDTTVLET LSNDFSMDNI SDSGASNETT NALQENSLAD FSLPQTPQTD NPSEGRGEGV 540
SKSFSDHGFY SPSSTLGDSP LVDDPLEYQA GLLVQNAIQQ AIAEQVDKAV SKTSRDGAEQ 600
QGPEATVEEA EAAAFGSEKP QSMFEPPQVS SPVQEKRDVL PKILPAEDRA LRERGPPQPL 660
PAVQPSGPIN MEETRPEGSY FSKYSEAAEL RSTASLLATQ ESDVMVGPFK LRSRKQRTLS 720
MIEEEIRAAQ EREEELKRQR QVLQSTQSPR TKNAPSLPSR TCYKTAPGKI EKVKPPPSPT 780
TEGPSLQPDL APEEAAGTQR PKNLMQTLME DYETHKSKRR ERMDDSSVLE ATRVNRRKSA 840
LALRWEAGIY ANQEEEDNE 859

Gene Ontology

GO:0019899; F:enzyme binding; NAS:UniProtKB.

Interpro

IPR018459; RII_binding_1.

Pfam

PF10522; RII_binding_1

SMART

PROSITE

PRINTS