CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028160
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nbs, isoform E 
Protein Synonyms/Alias
  
Gene Name
 nbs 
Gene Synonyms/Alias
 CG6754; Dmel_CG6754 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
412AKSDIATKLTMKSKNacetylation[1]
465PPVPAASKHITRKTKacetylation[1]
806QKRIVALKSLRLADGacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 818 AA 
Protein Sequence
MFVLTKDDEK FVLFPGKKVY TIGRLATDLI VAQDLSISRN HAQLLIQTEA DGDDTLHIED 60
LGSRYGTFIF PKNSQKPRKV PAKTSTPLPV GTRLRFGANM SIWQVTQLKL VTTVSALTRS 120
EVQELTKMLE PMGGTVTSNW TEECSHLTMN EVSVTVKLLH AMLENKPIVT FPYWRKMLQA 180
AQSIHVKEGW PQPEDYQPTN IDVTWRPERT RLFAGKTFVF MNRKHFDMYG SVVQKAGATC 240
KDINSGVRKT FLTKSDVIVI QYVPSSQSQA TESINSIQDR YILEQNGRRI IQEYEIGMAL 300
IHCSITEFCN PTHKFISDSL PTTESVTSSM AFNSSIIVPN TERHSAQSNA TPISELVVPE 360
SIECEMEQDA SKPHSEDQAS LRKRSHASTV DSSDEEKKST LSKRAKSDIA TKLTMKSKNA 420
ILLDSSLEED VTPAPAPAPV QRVTRQSKAI AEEKSVHPPV PAASKHITRK TKQVFCVDSS 480
DEENENARKP KETPAPTIPS MAKKKTEAPV ATRISPRLNG KSLATNITNQ PADKHAVPAK 540
RPVLSVASSD EEDEGDLFQF RKSPQKPAET VVQPRIAGKG NAPARISVVD FLEKSQAQEP 600
APVPPQLESQ SQTQPRKRLR LELLNESDSD DCDNLFNFAD SKKKRKTQEA QRNDDSTDGL 660
FNFNSERPSD HDDEDSRLTE PFVPETESKK QSKYIVAPRR DRPKKVDISG WLSCSRLNDN 720
IKSEIDADSV KMETSIKADP DEEQWLAAMK DSIEVRMCNL NIVIRSQEEV DASLEDSVNK 780
HGGRKNFKKF VKTKNPHPQK RIVALKSLRL ADGMVTCV 818 
Gene Ontology
 GO:0045003; P:double-strand break repair via synthesis-dependent strand annealing; IMP:FlyBase.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IMP:FlyBase.
 GO:0007095; P:mitotic G2 DNA damage checkpoint; IMP:FlyBase.
 GO:0042770; P:signal transduction in response to DNA damage; IMP:FlyBase.
 GO:0016233; P:telomere capping; IDA:FlyBase. 
Interpro
 IPR001357; BRCT_dom.
 IPR000253; FHA_dom.
 IPR016592; Nibrin_met.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF00533; BRCT
 PF00498; FHA 
SMART
 SM00292; BRCT
 SM00240; FHA 
PROSITE
 PS50006; FHA_DOMAIN 
PRINTS