CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044763
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Integrator complex subunit 1 
Protein Synonyms/Alias
  
Gene Name
 Ints1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
74KTTSTLLKPAPSGLPacetylation[1, 2]
127AEAAVAEKRAISPSIacetylation[2]
1900DANMACRKLAVAHPVubiquitination[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2222 AA 
Protein Sequence
MTERASDSRR LLPGEGASSR GARAAGRMNR AKPTTVRRPS AAAKPSGHPP PGDFIALGSK 60
GQASESKTTS TLLKPAPSGL PSERKRDASA SLSGTSALTG LTKRPKLSST PPLSALGRLA 120
EAAVAEKRAI SPSIKEPSVV PIEVLPTVLL DEIEAAELEG NDDRIEGVLC GAVKQLKVTR 180
AKPDSTLYLS LMYLAKIKPN IFATEGVIEA LCSLLRRDAS VNFKAKGNSL VSVLACNLLM 240
AAYEEDENWP EIFVKVYIED SLGERIWVDS PHCRTFVDNI QTAFNTKMPP KSVLLQGEGA 300
RSGGELGAGS SPHPSLTEEE DSQTELLIAE EKLSPEQEGQ LMPRPRYDEL TESVEEYVLD 360
MLRDQLNRRQ PIDNVSRNLL RLLTATCGYK EVRLLAVQRL EMWLQNPKLT RPAQDLLMSV 420
CMNCNSHGSE DMDVISHLIK IRLKPKVLLN HYMLCIRELL NAHKDNLGTT IKFVIFNELS 480
NARNPNNMQI LYTVLQHSSE LAPKFLAMVF QDLLTNKDDY LRASRALLRE IIKQTKHEIN 540
FQAFCLGLMQ ERKEPQYLEM EFKERFVVHI TDVLAVSMML GITAQVKEAG VAWDKGEKRN 600
LEVLRTFQNQ IAAIQRDAVW WLHTVVPSVS KLAPKDYVHC LHKVLFTEQP ETYYKWDNWP 660
PESDRNFFLR LCSEVPILED TLMRVLVIGL SRELPLGPAD AMELADHLVK RAAAVQADDV 720
EVLKVERIQL IDAVLNLCTY HHPENIQLPP GYQPPNLAIS TLYWKAWPLL LVVAAFNPEN 780
IGLAAWEEYP TLKMLMEMVM TNNYSYPPCT LTDEETRTEM INRELQISQR EKQEILAFEG 840
HLAAASTKQT ITESSSLLLS QLTSLDPQGP PRRPPPHILD QVKALNQSLR LGHLLCRSRN 900
PDFLLHIIQR QASSQSMPWL ADLVQSSEGS LDVLPVQCLC EFLLHDAADS TASGEEDDEG 960
ESREQKAKKR QRQQKQRQLL GRLQDLLLGP KADEQTTCEV LDYFLRRLGS SQVASRVLAM 1020
KGLSLVLSEG GLRDKEEKEP PMEEDIGETD ALQGYQWLLR DLPRLPLFDS VRTTTALALQ 1080
QAIHMETDPQ TISAYLIYLS QHTPVEEQGP HSDLALDVAR LVVERSTIMA HLFSKPSCST 1140
ASDAVLSALL SVFSRYVRRM RKSKEGEEVY SWSESQDQVF LRWSSGETAT MHILVVHAMV 1200
ILLTLGPPRS GDSEFSELLD IWFPEKKPLP TAFLVDTSEE ALLLPDWLKL RMIRSEVPRL 1260
VDAALQDLEP QQLLLFVQSF GIPVSSMSKL LQYLDQAVAQ DPQTLEQNIM DKNYMAHLVE 1320
VQHERGASGG QTFHSLLTAS LPPRRDSTEA PKPESSPEPP PGQGRTRAGT QVPVLGPEDD 1380
LAGIFLQIFP LSPDPRWQSS SPRPLALALQ QALGQELARV RQGNPEVPGI TVRLLQAMTT 1440
LLSSPHGGTL ALAMHHSHFL SCPLMRQLYQ YQRAVPQDTG FSSLFLKVLM QILQWLDSPA 1500
VEDGPLQAQL KLFATRYSAR HRISDVRSGL LHLADALSFH GDLEVANSTA RAVIATLRSG 1560
EKCPVEPELI SKVLRGLIEV RSPHLEELLT ALFSATTETS CPSPASGPIV VVSSLLLQEK 1620
EELLGPSKQE VEGASTEAMR LGPASGLLVD WLETLDPEVV CSCPDLQWKL LFSRRKGKGH 1680
ISAQVLSFRP YLLALLTHQA SWSTLHCCIR VLLGKSREQR LDPSASLDFL WACIHVPRIW 1740
QGRDQRTPQK RREELVLHVQ GPELLSLVEL ILSEAETRSQ DGDSAARTLI QTRLPLLLSC 1800
CRSNDESIGK VTEHLTSCIQ QWGDSVLGQR CRDLLLQLYL QRPEVRVPVP EVLLQSEGAT 1860
SSSICKLDGL VHRFITLLAD TSDSRSSESR VADANMACRK LAVAHPVLLL RHLPMIAALL 1920
HGRTHLNFQE FRQQNHLAFF LHVLGILELL QPRVFQSEHQ GALWDCLRSF IRLLLNYRKS 1980
SRHLAPFISK FVQFIHKYVG CSAPAAVAFL QKHAEPLHDL SFDNSDLVML KSLLAGLSLP 2040
SRDGRTDQGL DEEGEDERSA GSLPLVSVSL STPLTVADVA PHMKRLSRGR AVEDVLETLS 2100
DIDEMSRRRP EVLGFFSTNL QRLMSSAEES CRNLAFSLAL RSIQNNPSIA ADFLPTFMYC 2160
LGSRDFEVVQ TALRNLPEYT LLCQEHAAVL LHRAFLVGVY GQIDTSAQIS EALKILHMEA 2220
VM 2222 
Gene Ontology
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0001833; P:inner cell mass cell proliferation; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:MGI.
 GO:0034474; P:U2 snRNA 3'-end processing; IMP:MGI. 
Interpro
 IPR022145; DUF3677. 
Pfam
 PF12432; DUF3677 
SMART
  
PROSITE
  
PRINTS