| Tag | Content |
|---|
| CPLM ID | CPLM-004444 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Carboxylesterase 1D |
Protein Synonyms/Alias | Carboxyesterase ES-10; Carboxylesterase 3; ES-HVEL; Fatty acid ethyl ester synthase; FAEE synthase; Liver carboxylesterase 10; pI 6.1 esterase |
Gene Name | Ces1d |
Gene Synonyms/Alias | Ces3 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 304 | SLKLNLFKLDLLGNP | acetylation | [1] | | 338 | PEEILAEKSFNTVPY | acetylation | [1] | | 540 | AAQRLKDKEVAFWSE | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Major lipase in white adipose tissue (By similarity). Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters. |
Sequence Annotation | MOTIF 562 565 Prevents secretion from ER (Potential).
ACT_SITE 221 221 Acyl-ester intermediate (By similarity).
ACT_SITE 353 353 Charge relay system (By similarity).
ACT_SITE 466 466 Charge relay system (By similarity).
CARBOHYD 79 79 N-linked (GlcNAc...) (By similarity).
CARBOHYD 489 489 N-linked (GlcNAc...) (Potential).
DISULFID 87 116 By similarity.
DISULFID 273 284 By similarity. |
Keyword | Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Hydrolase; Lipid degradation; Lipid droplet; Lipid metabolism; Reference proteome; Serine esterase; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 565 AA |
Protein Sequence | MRLYPLVWLF LAACTAWGYP SSPPVVNTVK GKVLGKYVNL EGFAQPVAVF LGIPFAKPPL 60
GSLRFAPPQP AEPWNFVKNT TSYPPMCSQD AVGGQVLSEL FTNRKENIPL QFSEDCLYLN 120
VYTPADLTKN SRLPVMVWIH GGGLVVGGAS TYDGQVLSAH ENVVVVTIQY RLGIWGFFST 180
GDEHSQGNWG HLDQVAALHW VQDNIANFGG NPGSVTIFGE SAGGFSVSAL VLSPLAKNLF 240
HRAISESGVV LTSALITTDS KPIANLIATL SGCKTTTSAV MVHCLRQKTE DELLETSLKL 300
NLFKLDLLGN PKESYPFLPT VIDGVVLPKT PEEILAEKSF NTVPYIVGIN KQEFGWIIPT 360
LMGYPLSEGK LDQKTAKSLL WKSYPTLKIS EKMIPVVAEK YFGGTDDPAK RKDLFQDLVA 420
DVMFGVPSVM VSRSHRDAGA PTFMYEFEYR PSFVSAMRPK TVIGDHGDEL FSVFGSPFLK 480
DGASEEETNL SKMVMKYWAN FARNGNPNGG GLPHWPEYDQ KEGYLKIGAS TQAAQRLKDK 540
EVAFWSELRA KEAAEEPSHW KHVEL 565 |
Gene Ontology | GO:0005829; C:cytosol; ISS:UniProtKB. GO:0005788; C:endoplasmic reticulum lumen; ISS:UniProtKB. GO:0005811; C:lipid particle; ISS:UniProtKB. GO:0004091; F:carboxylesterase activity; IMP:RGD. GO:0030339; F:fatty-acyl-ethyl-ester synthase activity; IEA:EC. GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:EC. GO:0080032; F:methyl jasmonate esterase activity; IEA:EC. GO:0080031; F:methyl salicylate esterase activity; IEA:EC. GO:0050253; F:retinyl-palmitate esterase activity; IEA:EC. GO:0004771; F:sterol esterase activity; ISS:UniProtKB. GO:0004806; F:triglyceride lipase activity; ISS:UniProtKB. GO:0046464; P:acylglycerol catabolic process; ISS:UniProtKB. |
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SMART | |
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