CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006185
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fructose-2,6-bisphosphatase 
Protein Synonyms/Alias
  
Gene Name
 FBP26 
Gene Synonyms/Alias
 YJL155C; J0575 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
204IEEVVINKIRTYLESubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 This is predominantly if not solely a fructose-2,6- bisphosphatase. 
Sequence Annotation
 NP_BIND 20 27 ATP (By similarity).
 REGION 1 223 6-phosphofructo-2-kinase (By similarity).
 REGION 224 452 Fructose-2,6-bisphosphatase.
 ACT_SITE 104 104 Potential.
 ACT_SITE 232 232 Tele-phosphohistidine intermediate (By
 ACT_SITE 302 302 Potential.
 ACT_SITE 367 367 Proton donor (By similarity).
 BINDING 78 78 Fructose-6-phosphate (By similarity).
 BINDING 169 169 Fructose-6-phosphate (By similarity).
 MOD_RES 435 435 Phosphoserine.
 MOD_RES 446 446 Phosphoserine.  
Keyword
 ATP-binding; Complete proteome; Hydrolase; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 452 AA 
Protein Sequence
MGYSTISNDN DIKVCVIMVG LPARGKSFIS QKIIRYLSWL SIKAKCFNVG NYRRDVSGNV 60
PMDAEFFNFE NTDNFKLREL AAQNAIKDIV NFFTKEDGSV AVFDATNSTR KRRKWLKDIC 120
EKNNIQPMFL ESWSNDHELI INNAKDIGST SPDYENSEPH VAEADFLERI RQYERFYEPL 180
DPQKDKDMTF IKLVNIIEEV VINKIRTYLE SRIVFYVMNI RPKPKYIWLS RHGESIYNVE 240
KKIGGDSSLS ERGFQYAKKL EQLVKESAGE INLTVWTSTL KRTQQTANYL PYKKLQWKAL 300
DELDAGVCDG MTYEEIEKEY PEDFKARDND KYEYRYRGGE SYRDVVIRLE PVIMELERQE 360
NVLIITHQAV LRCIYAYFMN VPQEESPWMS IPLHTLIKLE PRAYGTKVTK IKANIPAVST 420
YKEKGTSQVG ELSQSSTKLH QLLNDSPLED KF 452 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IMP:SGD.
 GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
 GO:0006000; P:fructose metabolic process; IEA:InterPro.
 GO:0006006; P:glucose metabolic process; IMP:SGD. 
Interpro
 IPR003094; 6Pfruct_kin.
 IPR013079; 6Phosfructo_kin.
 IPR016260; Bifunct_6PFK/fruc_bisP_Ptase.
 IPR013078; His_Pase_superF_clade-1.
 IPR027417; P-loop_NTPase.
 IPR001345; PG/BPGM_mutase_AS. 
Pfam
 PF01591; 6PF2K
 PF00300; His_Phos_1 
SMART
 SM00855; PGAM 
PROSITE
 PS00175; PG_MUTASE 
PRINTS
 PR00991; 6PFRUCTKNASE.