CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042972
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Chromodomain-helicase-DNA-binding protein 8 
Protein Synonyms/Alias
  
Gene Name
 CHD8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
24PQASAWKKLELSHEYubiquitination[1]
284VELTNIQKKYYRAILubiquitination[1]
293YYRAILEKNFSFLSKubiquitination[2]
319NTMMELRKCCNHPYLubiquitination[1, 2]
366GKLVLIDKLLPKLKAubiquitination[1, 2]
476CHRIGQSKAVKVYRLacetylation[2]
496YEREMFDKASLKLGLubiquitination[1]
500MFDKASLKLGLDKAVubiquitination[1]
505SLKLGLDKAVLQSMSubiquitination[2]
527GIQQFSKKEIEDLLRubiquitination[1]
602DDPNFWQKWAKKADLubiquitination[1]
617DMDLLNSKNNLVIDTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 873 AA 
Protein Sequence
XKRIQSRHPE LKRVNRPQAS AWKKLELSHE YKNRNQLREY QLEGVNWLLF NWYNRQNCIL 60
ADEMGLGKTI QSIAFLQEVY NVGIHGPFLV IAPLSTITNW EREFNTWTEM NTIVYHGSLA 120
SRQMIQQYEM YCKDSRGRLI PGAYKFDALI TTFEMILSDC PELREIEWRC VIIDEAHRLK 180
NRNCKLLDSL KHMDLEHKVL LTGTPLQNTV EELFSLLHFL EPSQFPSESE FLKDFGDLKT 240
EEQVQKLQAI LKPMMLRRLK EDVEKNLAPK QETIIEVELT NIQKKYYRAI LEKNFSFLSK 300
GAGHTNMPNL LNTMMELRKC CNHPYLINGA EEKILTEFRE ACHIIPHDFH LQAMVRSAGK 360
LVLIDKLLPK LKAGGHKVLI FSQMVRCLDI LEDYLIQRRY LYERIDGRVR GNLRQAAIDR 420
FSKPDSDRFV FLLCTRAGGL GINLTAADTC IIFDSDWNPQ NDLQAQARCH RIGQSKAVKV 480
YRLITRNSYE REMFDKASLK LGLDKAVLQS MSGRDGNITG IQQFSKKEIE DLLRKGAYAA 540
IMEEDDEGSK FCEEDIDQIL LRRTTTITIE SEGKGSTFAK ASFVASENRT DISLDDPNFW 600
QKWAKKADLD MDLLNSKNNL VIDTPRVRKQ TRHFSTLKDD DLVEFSDLES EDDERPRSRR 660
HDRHHAYGRT DCFRVEKHLL VYGWGRWRDI LSHGRFKRRM TERDVETICR AILVYCLLHY 720
RGDENIKGFI WDLISPAENG KTKELQNHSV FDVSPFPGLS IPVPRGRKGK KVKSQSTFDI 780
HKADWIRKYN PDTLFQDESY KKHLKHQCNK VLLRVRMLYY LRQEVIGDQA EKVLGGAIAS 840
EIDIWFPVVD QLEVPTTWWD SEADKSLLIG VFK 873 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004386; F:helicase activity; IEA:InterPro. 
Interpro
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000330; SNF2_N. 
Pfam
 PF00271; Helicase_C
 PF00176; SNF2_N 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS