CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026915
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MCG142115, isoform CRA_b 
Protein Synonyms/Alias
 MKIAA0778 protein 
Gene Name
 Atp1a2 
Gene Synonyms/Alias
 mKIAA0778; mCG_142115 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
41GKKKQKEKELDELKKubiquitination[1]
47EKELDELKKEVAMDDubiquitination[1]
48KELDELKKEVAMDDHubiquitination[1]
56EVAMDDHKLSLDELGubiquitination[1]
65SLDELGRKYQVDLSKubiquitination[1]
72KYQVDLSKGLTNQRAubiquitination[1]
167YQEAKSSKIMDSFKNubiquitination[1]
173SKIMDSFKNMVPQQAubiquitination[1]
188LVIREGEKMQINAEEubiquitination[1]
205VGDLVEVKGGDRVPAubiquitination[1]
223IISSHGCKVDNSSLTubiquitination[1]
424QSGATFDKRSPTWTAubiquitination[1]
445LCNRAVFKAGQENISubiquitination[1]
455QENISVSKRDTAGDAubiquitination[1]
518QSHVLVMKGAPERILubiquitination[1]
536STILVQGKEIPLDKEubiquitination[1]
542GKEIPLDKEMQDAFQubiquitination[1]
574QLNLPSGKFPRGFKFubiquitination[1]
580GKFPRGFKFDTDELNubiquitination[1]
671QVNPREAKACVVHGSubiquitination[1]
681VVHGSDLKDMTSEQLubiquitination[1]
737NDSPALKKADIGIAMubiquitination[1]
853PRNSQTDKLVNERLIubiquitination[1]
1018YPGGWVEKETYY***ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Hydrolase; Membrane; Nucleotide-binding; Phosphoprotein; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1022 AA 
Protein Sequence
PFQPRSPQPL CPKMGRGAGR EYSPAATTAE NGGGKKKQKE KELDELKKEV AMDDHKLSLD 60
ELGRKYQVDL SKGLTNQRAQ DILARDGPNA LTPPPTTPEW VKFCRQLFGG FSILLWIGAL 120
LCFLAYGILA AMEDEPSNDN LYLGIVLAAV VIVTGCFSYY QEAKSSKIMD SFKNMVPQQA 180
LVIREGEKMQ INAEEVVVGD LVEVKGGDRV PADLRIISSH GCKVDNSSLT GESEPQTRSP 240
EFTHENPLET RNICFFSTNC VEGTARGIVI ATGDRTVMGR IATLASGLEV GQTPIAMEIE 300
HFIQLITGVA VFLGVSFFVL SLILGYSWLE AVIFLIGIIV ANVPEGLLAT VTVCLTLTAK 360
RMARKNCLVK NLEAVETLGS TSTICSDKTG TLTQNRMTVA HMWFDNQIHE ADTTEDQSGA 420
TFDKRSPTWT ALSRIAGLCN RAVFKAGQEN ISVSKRDTAG DASESALLKC IELSCGSVRK 480
MRDRNPKVAE IPFNSTNKYQ LSIHEREDSP QSHVLVMKGA PERILDRCST ILVQGKEIPL 540
DKEMQDAFQN AYMELGGLGE RVLGFCQLNL PSGKFPRGFK FDTDELNFPT EKLCFVGLMS 600
MIDPPRAAVP DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI 660
PVSQVNPREA KACVVHGSDL KDMTSEQLDE ILRDHTEIVF ARTSPQQKLI IVEGCQRQGA 720
IVAVTGDGVN DSPALKKADI GIAMGISGSD VSKQAADMIL LDDNFASIVT GVEEGRLIFD 780
NLKKSIAYTL TSNIPEITPF LLFIIANIPL PLGTVTILCI DLGTDMVPAI SLAYEAAESD 840
IMKRQPRNSQ TDKLVNERLI SMAYGQIGMI QALGGFFTYF VILAENGFLP SRLLGIRLDW 900
DDRTTNDLED SYGQEWTYEQ RKVVEFTCHT AFFASIVVVQ WADLIICKTR RNSVFQQGMK 960
NKILIFGLLE ETALAAFLSY CPGMGVALRM YPLNLLIFIY DEVRKLILRR YPGGWVEKET 1020
YY 1022 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042383; C:sarcolemma; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0019829; F:cation-transporting ATPase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0015077; F:monovalent inorganic cation transmembrane transporter activity; IEA:InterPro.
 GO:0008344; P:adult locomotory behavior; IMP:MGI.
 GO:0006754; P:ATP biosynthetic process; IEA:InterPro.
 GO:0040011; P:locomotion; IMP:MGI.
 GO:0045822; P:negative regulation of heart contraction; IMP:MGI.
 GO:0045988; P:negative regulation of striated muscle contraction; IMP:MGI.
 GO:0001504; P:neurotransmitter uptake; IMP:MGI.
 GO:0051481; P:reduction of cytosolic calcium ion concentration; IMP:MGI.
 GO:0008217; P:regulation of blood pressure; IGI:MGI.
 GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process; IMP:MGI.
 GO:0006940; P:regulation of smooth muscle contraction; IMP:MGI.
 GO:0002026; P:regulation of the force of heart contraction; IMP:MGI.
 GO:0019229; P:regulation of vasoconstriction; IMP:MGI.
 GO:0008542; P:visual learning; IMP:MGI. 
Interpro
 IPR006068; ATPase_P-typ_cation-transptr_C.
 IPR004014; ATPase_P-typ_cation-transptr_N.
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR005775; ATPase_P-typ_Na/K_IIC.
 IPR018303; ATPase_P-typ_P_site.
 IPR023298; ATPase_P-typ_TM_dom.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 
Pfam
 PF00689; Cation_ATPase_C
 PF00690; Cation_ATPase_N
 PF00122; E1-E2_ATPase
 PF00702; Hydrolase 
SMART
 SM00831; Cation_ATPase_N 
PROSITE
 PS00154; ATPASE_E1_E2 
PRINTS
 PR00119; CATATPASE.