| Tag | Content |
|---|
| CPLM ID | CPLM-002394 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Multidrug resistance protein 1B |
Protein Synonyms/Alias | ATP-binding cassette sub-family B member 1B; P-glycoprotein 1; CD243 |
Gene Name | Abcb1b |
Gene Synonyms/Alias | Abcb1; Mdr1; Mdr1b; Pgy1; Pgy1-1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 410 | RSEVQILKGLNLKVK | ubiquitination | [1] | | 417 | KGLNLKVKSGQTVAL | ubiquitination | [1] | | 504 | DEIEKAVKEANAYDF | ubiquitination | [1] | | 514 | NAYDFIMKLPHQFDT | ubiquitination | [1] | | 1218 | VVQEALDKAREGRTC | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. |
Sequence Annotation | DOMAIN 50 356 ABC transmembrane type-1 1.
DOMAIN 391 627 ABC transporter 1.
DOMAIN 709 998 ABC transmembrane type-1 2.
DOMAIN 1033 1271 ABC transporter 2.
NP_BIND 426 433 ATP 1 (By similarity).
NP_BIND 1068 1075 ATP 2 (By similarity).
MOD_RES 641 641 Phosphotyrosine.
MOD_RES 659 659 Phosphoserine.
CARBOHYD 73 73 N-linked (GlcNAc...) (Potential).
CARBOHYD 91 91 N-linked (GlcNAc...) (Potential).
CARBOHYD 96 96 N-linked (GlcNAc...) (Potential).
CARBOHYD 103 103 N-linked (GlcNAc...) (Potential). |
Keyword | ATP-binding; Cell membrane; Complete proteome; Glycoprotein; Hydrolase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1276 AA |
Protein Sequence | MEFEENLKGR ADKNFSKMGK KSKKEKKEKK PAVGVFGMFR YADWLDKLCM ILGTLAAIIH 60
GTLLPLLMLV FGNMTDSFTK AEASILPSIT NQSGPNSTLI ISNSSLEEEM AIYAYYYTGI 120
GAGVLIVAYI QVSLWCLAAG RQIHKIRQKF FHAIMNQEIG WFDVHDVGEL NTRLTDDVSK 180
INDGIGDKIG MFFQSITTFL AGFIIGFISG WKLTLVILAV SPLIGLSSAL WAKVLTSFTN 240
KELQAYAKAG AVAEEVLAAI RTVIAFGGQQ KELERYNKNL EEAKNVGIKK AITASISIGI 300
AYLLVYASYA LAFWYGTSLV LSNEYSIGEV LTVFFSILLG TFSIGHLAPN IEAFANARGA 360
AFEIFKIIDN EPSIDSFSTK GYKPDSIMGN LEFKNVHFNY PSRSEVQILK GLNLKVKSGQ 420
TVALVGNSGC GKSTTVQLMQ RLYDPLEGVV SIDGQDIRTI NVRYLREIIG VVSQEPVLFA 480
TTIAENIRYG REDVTMDEIE KAVKEANAYD FIMKLPHQFD TLVGERGAQL SGGQKQRIAI 540
ARALVRNPKI LLLDEATSAL DTESEAVVQA ALDKAREGRT TIVIAHRLST VRNADVIAGF 600
DGGVIVEQGN HDELMREKGI YFKLVMTQTR GNEIEPGNNA YGSQSDTDAS ELTSEESKSP 660
LIRRSIYRSV HRKQDQERRL SMKEAVDEDV PLVSFWRILN LNLSEWPYLL VGVLCAVING 720
CIQPVFAIVF SRIVGVFSRD DDHETKRQNC NLFSLFFLVM GLISFVTYFF QGFTFGKAGE 780
ILTKRVRYMV FKSMLRQDIS WFDDHKNSTG SLTTRLASDA SSVKGAMGAR LAVVTQNVAN 840
LGTGVILSLV YGWQLTLLLV VIIPLIVLGG IIEMKLLSGQ ALKDKKQLEI SGKIATEAIE 900
NFRTIVSLTR EQKFETMYAQ SLQVPYRNAM KKAHVFGITF SFTQAMMYFS YAACFRFGAY 960
LVAQQLMTFE NVMLVFSAVV FGAMAAGNTS SFAPDYAKAK VSASHIIRII EKTPEIDSYS 1020
TEGLKPTLLE GNVKFNGVQF NYPTRPNIPV LQGLSLEVKK GQTLALVGSS GCGKSTVVQL 1080
LERFYDPMAG SVFLDGKEIK QLNVQWLRAH LGIVSQEPIL FDCSIAENIA YGDNSRAVSH 1140
EEIVRAAKEA NIHQFIDSLP DKYNTRVGDK GTQLSGGQKQ RIAIARALVR QPHILLLDEA 1200
TSALDTESEK VVQEALDKAR EGRTCIVIAH RLSTIQNADL IVVIENGKVK EHGTHQQLLA 1260
QKGIYFSMVQ AGAKRS 1276 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IBA:RefGenome. GO:0000139; C:Golgi membrane; IBA:RefGenome. GO:0016021; C:integral to membrane; IBA:RefGenome. GO:0046581; C:intercellular canaliculus; IDA:MGI. GO:0005739; C:mitochondrion; IDA:MGI. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IBA:RefGenome. GO:0008559; F:xenobiotic-transporting ATPase activity; IEA:EC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |