UniProt Accession

 CLD12_HUMAN; P56749; D6W5Q4; Q7LDZ0 

Genbank Protein ID

 AJ250713; AL136770; AC006153; CH236949; CH471091; CH471091; BC036754; BC068532 

Genbank Nucleotide ID

 CAB60617.1; CAB66704.1; AAP22363.1; EAL24163.1; EAW76876.1; EAW76877.1; AAH36754.1; AAH68532.1 

Protein Name

 Claudin-12 

Protein Synonyms/Alias

  

Gene Name

 CLDN12 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
121	RSSVPNIKLAKCLVN	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). 

Sequence Annotation

 MOD_RES 228 228 Phosphoserine (By similarity).
 MOD_RES 231 231 Phosphoserine.  

Keyword

 Cell junction; Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Tight junction; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 244 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005923; C:tight junction; ISS:UniProtKB.
 GO:0042802; F:identical protein binding; ISS:UniProtKB.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0016338; P:calcium-independent cell-cell adhesion; ISS:UniProtKB.
 GO:0070830; P:tight junction assembly; TAS:Reactome. 

Interpro

 IPR013287; Claudin12.
 IPR017974; Claudin_CS. 

Pfam

  

SMART

  

PROSITE

 PS01346; CLAUDIN 

PRINTS

 PR01872; CLAUDIN12.