CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034709
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DOT1-like, histone H3 methyltransferase (S. cerevisiae) (Predicted), isoform CRA_a 
Protein Synonyms/Alias
 Protein Dot1l 
Gene Name
 Dot1l 
Gene Synonyms/Alias
 Dot1l_predicted; rCG_29188 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1250GEPVNSSKWKSTFSPacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1549 AA 
Protein Sequence
MGEKLELRLK SPVGAEPAVY PWPLPVYVSV LAENPGDKHH DAAHEIIETI RWVCEEIPDL 60
KLAMENYVLI DYDTKSFESM QRLCDKYNRA IDSIHQLWKG TTQPMKLNTR PSNGLLRHIL 120
QQVYNHSVTD PEKLNNYEPF SPEVYGETSF DLVAQMIDEI KMTEDDLFVD LGSGVGQVVL 180
QVAAATNCKH HYGVEKADIP AKYAETMDRE FRKWMKWYGK KHAEYTLERG DFLSEEWRER 240
IANTSVIFVN NFAFGPEVDH QLKERFANMK EGGRIVSSKP FAPLNFRINS RNLSDIGTIM 300
RVVELSPLKG SVSWTGKPVS YYLHTIDRTI LENYFSSLKN PKLREEQEAA RRRQQRENKS 360
NATTPTKVPE SKAAATEAPA DSGAEEEKSG VATVKKQSPS KARKKKLNKK GRKMAGRKRG 420
RPKKMSAASA DRKSKKSQST LDLLHSPPPA PPSASPQDAY RAPHSPFYQL PPSTPLHSPD 480
PLLVAPTPPA LQKLLESFKI QYLQFLAYTK TPQYKANLQQ LLDQEKEKNT QLLGTAQQLF 540
SHCQAQKEEI RRLFQQKLDE LGVKALTYND LIQAQKEISA HNQQLREQSE QLEKDNSELR 600
SQSLRLLRAR CEELRLDWST LSLENLRKEK QALRSQISEK QRHCLELQIS IVELEKTQRQ 660
QELLQLKSCV PPDDALSLHL RGKGALGREL ESDAGRLRLE LDCAKLSLPH LSSMSPELSM 720
NGHAASYELC GAASRPSSKQ NTPQYLASPL DQEVVPCTPS HSGRPRLEKL SGLALPDYTR 780
LSPAKIVLRR HLSQDHTGAS KAATSEPHPR PEHAKENSLP YQSPGLSNSM KLSPQDPPLA 840
SPATSPLTSE RGSEKGVKER AYSSHGETIT SLPVSIPLST VQPNKLPVSI PLASVVLPSR 900
AERARSTPSP VPQPRDSSST LEKQIGASTH GAGGAAAGSR SLTVAPTGFY AGSVAISGAL 960
ASSPAPLASG MESAVFEESS GPSSLFGTMG SRSTPPQHPP LLPQSRNSGP ASPAHQLAAS 1020
PRLSVTTQGS LPDTGKGELP ADPAFSDPES EAKRRIVFSI SAGASSRQSP STRHSPLTSG 1080
TRGDCVQSHG QDSRKRSRRK RASAGTPSLT TGVSPKRRAL PTVAGLFTQS SGSPLNLTSM 1140
VSNINQPLEI TAISSPESSL KSSPTPYQDH DQPPVLRKER PLGPTNGAHY SPLTSDEEPG 1200
SEDEPSSARI ERKIATISLE SKSPPKTLEN GGGLVGRKPV PSGEPVNSSK WKSTFSPISD 1260
LGLAKAMDSP LQASSALSHS PLFSFRPSLE EPAAEAKPST HPRKSFAGSL AAAEGPSPGT 1320
NPPNSLAFSG GLAADLGLHS FNDGASLSHK GPEVAGLSAS LSFPSQRGKD STTEANPFLS 1380
RRQPEGLGGL KGEGNASKES GESLPLCGPS DKVSLPHGSR ASKGRDRELD FKGGHNLFIS 1440
AAAVPPGGLL GGPGLVTVAS SAGSATPSAQ APRPFLSTFA PGPQFTLGPM SLQANLGSVA 1500
GSSVLQSLFS TVPAAAGLVH VSSTATRLTN SHTMGSFSSG VAGGTVGGN 1549 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:Compara.
 GO:0046425; P:regulation of JAK-STAT cascade; IEA:Compara.
 GO:2000677; P:regulation of transcription regulatory region DNA binding; IEA:Compara. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR013110; DOT1.
 IPR025789; Histone_H3-K79_MeTrfase.
 IPR021169; Histone_H3-K79_MeTrfase_met. 
Pfam
 PF08123; DOT1 
SMART
 SM00384; AT_hook 
PROSITE
 PS51569; DOT1 
PRINTS