CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022246
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Anoctamin-10 
Protein Synonyms/Alias
 Transmembrane protein 16K 
Gene Name
 ANO10 
Gene Synonyms/Alias
 TMEM16K 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
58LFRPLLNKYEQETLEubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. 
Sequence Annotation
  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Disease mutation; Membrane; Neurodegeneration; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 660 AA 
Protein Sequence
MKVTLSALDT SESSFTPLVV IELAQDVKEE TKEWLKNRII AKKKDGGAQL LFRPLLNKYE 60
QETLENQNLY LVGASKIRML LGAEAVGLVK ECNDNTMRAF TYRTRQNFKG FDDNNDDFLT 120
MAECQFIIKH ELENLRAKDE KMIPGYPQAK LYPGKSLLRR LLTSGIVIQV FPLHDSEALK 180
KLEDTWYTRF ALKYQPIENH RLESAYQNHL ILKVLVFNFL NCFASLFYIA FVLKDMKLLR 240
QSLATLLITS QILNQIMESF LPYWLQRKHG VRVKRKVQAL KADIDATLYE QVILEKEMGT 300
YLGTFDDYLE LFLQFGYVSL FSCVYPLAAA FAVLNNFTEV NSDALKMCRV FKRPFSEPSA 360
NIGVWQLAFE TMSVISVVTN CALIGMSPQV NAVFPESKAD LILIVVAVEH ALLALKFILA 420
FAIPDKPRHI QMKLARLEFE SLEALKQQQM KLVTENLKEE PMESGKEKAT 470 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005622; C:intracellular; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0034220; P:ion transmembrane transport; TAS:Reactome. 
Interpro
 IPR007632; Anoctamin. 
Pfam
 PF04547; Anoctamin 
SMART
  
PROSITE
  
PRINTS