UniProt Accession

 D6RAU1_HUMAN; D6RAU1 

Genbank Protein ID

 AL162271; AL391845; AL590822; AL645703 

Genbank Nucleotide ID

  

Protein Name

 Protein kinase C zeta type 

Protein Synonyms/Alias

  

Gene Name

 PRKCZ 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
86	VLLVRLKKNDQIYAM	ubiquitination	[1]
94	NDQIYAMKVVKKELV	ubiquitination	[1]
97	IYAMKVVKKELVHDD	ubiquitination	[1]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 136 AA 

Protein Sequence

Gene Ontology

 GO:0045179; C:apical cortex; IEA:Compara.
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0031252; C:cell leading edge; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0035748; C:myelin sheath abaxonal region; IEA:Compara.
 GO:0005635; C:nuclear envelope; IEA:Compara.
 GO:0016363; C:nuclear matrix; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005923; C:tight junction; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0015459; F:potassium channel regulator activity; IEA:Compara.
 GO:0004697; F:protein kinase C activity; IEA:Compara.
 GO:0031532; P:actin cytoskeleton reorganization; IEA:Compara.
 GO:0031584; P:activation of phospholipase D activity; IEA:Compara.
 GO:0032148; P:activation of protein kinase B activity; IEA:Compara.
 GO:0016477; P:cell migration; IEA:Compara.
 GO:0030010; P:establishment of cell polarity; IEA:Compara.
 GO:0008286; P:insulin receptor signaling pathway; IEA:Compara.
 GO:0007616; P:long-term memory; IEA:Compara.
 GO:0060291; P:long-term synaptic potentiation; IEA:Compara.
 GO:0060081; P:membrane hyperpolarization; IEA:Compara.
 GO:0000226; P:microtubule cytoskeleton organization; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0051346; P:negative regulation of hydrolase activity; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0001954; P:positive regulation of cell-matrix adhesion; IEA:Compara.
 GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; IEA:Compara.
 GO:0046326; P:positive regulation of glucose import; IEA:Compara.
 GO:0046628; P:positive regulation of insulin receptor signaling pathway; IEA:Compara.
 GO:2001181; P:positive regulation of interleukin-10 secretion; IEA:Compara.
 GO:2000667; P:positive regulation of interleukin-13 secretion; IEA:Compara.
 GO:0032753; P:positive regulation of interleukin-4 production; IEA:Compara.
 GO:2000664; P:positive regulation of interleukin-5 secretion; IEA:Compara.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; IEA:Compara.
 GO:0045630; P:positive regulation of T-helper 2 cell differentiation; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0070528; P:protein kinase C signaling cascade; IEA:Compara.
 GO:0072659; P:protein localization to plasma membrane; IEA:Compara.
 GO:0047496; P:vesicle transport along microtubule; IEA:Compara. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM 

PRINTS