| Tag | Content |
|---|
| CPLM ID | CPLM-015530 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cullin-associated NEDD8-dissociated protein 2 |
Protein Synonyms/Alias | Cullin-associated and neddylation-dissociated protein 2; TBP-interacting protein of 120 kDa B; TBP-interacting protein 120B; p120 CAND2 |
Gene Name | Cand2 |
Gene Synonyms/Alias | Kiaa0667; Tip120b |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 99 | CANMRSDKEQLRDIA | ubiquitination | [1] | | 438 | AQVPLVIKALQRQLK | ubiquitination | [1] | | 587 | TDLDQEVKERAISCV | ubiquitination | [1] | | 976 | YLLPRFRKQLAAGQP | ubiquitination | [1] | | 1195 | LTNPEVRKSPTVADF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes (By similarity). |
Sequence Annotation | REPEAT 2 39 HEAT 1.
REPEAT 44 81 HEAT 2.
REPEAT 83 119 HEAT 3.
REPEAT 129 167 HEAT 4.
REPEAT 171 208 HEAT 5.
REPEAT 210 246 HEAT 6.
REPEAT 254 291 HEAT 7.
REPEAT 326 367 HEAT 8.
REPEAT 371 408 HEAT 9.
REPEAT 431 468 HEAT 10.
REPEAT 516 553 HEAT 11.
REPEAT 564 603 HEAT 12.
REPEAT 607 644 HEAT 13.
REPEAT 647 684 HEAT 14.
REPEAT 689 726 HEAT 15.
REPEAT 730 769 HEAT 16.
REPEAT 771 812 HEAT 17.
REPEAT 856 893 HEAT 18.
REPEAT 895 930 HEAT 19.
REPEAT 932 965 HEAT 20.
REPEAT 966 1002 HEAT 21.
REPEAT 1006 1043 HEAT 22.
REPEAT 1047 1083 HEAT 23.
REPEAT 1104 1140 HEAT 24.
REPEAT 1156 1193 HEAT 25.
REPEAT 1203 1235 HEAT 26.
MOD_RES 2 2 N-acetylserine (By similarity). |
Keyword | Acetylation; Complete proteome; Nucleus; Reference proteome; Repeat; Ubl conjugation; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1235 AA |
Protein Sequence | MSTGAFYISS LLEKMTSSDK DFRFMATSDL MSELQKDSIQ LDEDSERKVV RTLLRLLEDR 60
SGEVQNLAVK CLGPLVGKVK EYQVENIVDT LCANMRSDKE QLRDIAGIGL KTVLSELPPA 120
ATGSGLAINV CRKITGQLTS AIAQQEDVAV QLEALDILSD MLSRLGAPLG TFHASLLHCL 180
LPQLSSPRLA VRKRTVVALG HLAAACSTDL FVELADHLVD RLPGPRAPAS PAAIRTLIQC 240
LGSVGRQAGH RLGAHLDRLV PMVEEFCNLD DDELRESCLQ AFEAFLRKCP KEMDPHVPNV 300
TSLCLQYMKH DPNYDHDSDD EEQMETEDSE FSEQESEDEY SDDDDMSWKV RRAAAKCMAA 360
LISSRPDLLP DFHCTLAPAL IRRFKEREEN VKADIFGAYI MLLRHTRPPK GWLEAVEEPT 420
QTGRNLNMLR AQVPLVIKAL QRQLKDRNVR TRQGCFNLFT ELAGVLPGSL AEHMAVLVSG 480
IVFSLADYSS SSTIRMDALA FLQGLLGTEP AEAFHPHLPT LLPPVMACVA DPFYKVAAEA 540
LLVLQELVRT LWPLDRPRLL DPEPYVGEMS TATLARLRAT DLDQEVKERA ISCVGHLVGH 600
LGDRLGDDLE PTLMLLLDRL RNEITRLPAV KALTLVAMSP LRLDLQPILA EALPILASFL 660
RKNQRALRLA TLAALDALAQ SQGLGLPPPA VRTVLTELPA LVSENDMHVA QLAVDFLTTV 720
TQTQPSSLVE VSGPVLGELL QLLHSPLLPA GVLAATEGFL QALVGTRPPC VEYSELISLL 780
TAPVYNQVGD GGPGLHKQVF HSLARCVAAL SAACPQEAAG TASRLVCDAK SPHSSTGVKV 840
LAFLSLAEVG QVAGPGPQRE LKTVLLEALG SPSEDVRAAA AYALGRVGAG NLPDFLPFLL 900
AQIEAQPRRQ YLLLHALREA LGAAQPDNLK PYVEDVWALL FQRCESPEEG TRCVVAECIG 960
KLVFVNPPYL LPRFRKQLAA GQPYTRSTVI TAVKFLISDQ PHSIDPLLKS FIAEFMESLQ 1020
DPDLNVRRAT LTFFNSAVHN KPSLVRDLLD DILPLLYQET KIRRDLIREV EMGPFKHTVD 1080
DGLDVRKAAF ECMYSLLESC LGQLDMCEFL NHVEDGLKDH YDIRMLTFIM LARLATLCPA 1140
PVLQRVDRLI EPLRATCTAK VKAGSVKQEL EKQEELKRSA MRAVAALLTN PEVRKSPTVA 1200
DFSAQIRSNP ELTTLFESIQ KDTASGPSTD SMELS 1235 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |