UniProt Accession

 FNTB_RAT; Q02293 

Genbank Protein ID

 M69056; BC087675 

Genbank Nucleotide ID

 AAA41176.1; AAH87675.1 

Protein Name

 Protein farnesyltransferase subunit beta 

Protein Synonyms/Alias

 FTase-beta; CAAX farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta 

Gene Name

 Fntb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
83	EKHFHYLKRGLRQLT	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. 

Sequence Annotation

 REPEAT 123 164 PFTB 1.
 REPEAT 174 215 PFTB 2.
 REPEAT 222 263 PFTB 3.
 REPEAT 270 312 PFTB 4.
 REPEAT 332 374 PFTB 5.
 METAL 297 297 Zinc.
 METAL 299 299 Zinc.
 METAL 362 362 Zinc.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Metal-binding; Prenyltransferase; Reference proteome; Repeat; Transferase; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 437 AA 

Protein Sequence

Gene Ontology

 GO:0005875; C:microtubule associated complex; IEA:Compara.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0005965; C:protein farnesyltransferase complex; IEA:InterPro.
 GO:0004311; F:farnesyltranstransferase activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004660; F:protein farnesyltransferase activity; IDA:RGD.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0045787; P:positive regulation of cell cycle; IMP:RGD.
 GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.
 GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Compara.
 GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IMP:RGD.
 GO:0018343; P:protein farnesylation; IEA:InterPro.
 GO:0034097; P:response to cytokine stimulus; IMP:RGD.
 GO:0010035; P:response to inorganic substance; IMP:RGD.
 GO:0014070; P:response to organic cyclic compound; IMP:RGD.
 GO:0042060; P:wound healing; IEA:Compara. 

Interpro

 IPR026872; FTB.
 IPR001330; Prenyltrans.
 IPR008930; Terpenoid_cyclase/PrenylTrfase. 

Pfam

 PF00432; Prenyltrans 

SMART

  

PROSITE

  

PRINTS