CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008290
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serpin B8 
Protein Synonyms/Alias
 Cytoplasmic antiproteinase 2; CAP-2; CAP2; Peptidase inhibitor 8; PI-8 
Gene Name
 SERPINB8 
Gene Synonyms/Alias
 PI8 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
96ANRLFGEKTCDFLPDubiquitination[1]
105CDFLPDFKEYCQKFYubiquitination[1]
130EDTEECRKHINDWVAubiquitination[1]
139INDWVAEKTEGKISEubiquitination[1]
143VAEKTEGKISEVLDAubiquitination[1]
170NAIYFKGKWNEQFDRubiquitination[1]
258KAWTNSEKLTKSKVQubiquitination[1]
263SEKLTKSKVQVFLPRubiquitination[1]
272QVFLPRLKLEESYDLubiquitination[1]
296IDAFDEAKADFSGMSubiquitination[2]
306FSGMSTEKNVPLSKVubiquitination[1]
312EKNVPLSKVAHKCFVubiquitination[1]
316PLSKVAHKCFVEVNEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Polymorphism; Protease inhibitor; Reference proteome; Serine protease inhibitor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 374 AA 
Protein Sequence
MDDLCEANGT FAISLFKILG EEDNSRNVFF SPMSISSALA MVFMGAKGST AAQMSQALCL 60
YKDGDIHRGF QSLLSEVNRT GTQYLLRTAN RLFGEKTCDF LPDFKEYCQK FYQAELEELS 120
FAEDTEECRK HINDWVAEKT EGKISEVLDA GTVDPLTKLV LVNAIYFKGK WNEQFDRKYT 180
RGMLFKTNEE KKTVQMMFKE AKFKMGYADE VHTQVLELPY VEEELSMVIL LPDDNTDLAV 240
VEKALTYEKF KAWTNSEKLT KSKVQVFLPR LKLEESYDLE PFLRRLGMID AFDEAKADFS 300
GMSTEKNVPL SKVAHKCFVE VNEEGTEAAA ATAVVRNSRC SRMEPRFCAD HPFLFFIRHH 360
KTNCILFCGR FSSP 374 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:UniProtKB.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome. 
Interpro
 IPR023795; Protease_inhib_I4_serpin_CS.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 
Pfam
 PF00079; Serpin 
SMART
 SM00093; SERPIN 
PROSITE
 PS00284; SERPIN 
PRINTS