CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030625
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable ATP-dependent RNA helicase DDX58 
Protein Synonyms/Alias
 cDNA FLJ44001 fis, clone TESTI4022716, highly similar to Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) 
Gene Name
 DDX58 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
44KRLQPEFKTRIIPTDubiquitination[1]
101ENWPKTLKLALEKERubiquitination[1]
106TLKLALEKERNKFSEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 854 AA 
Protein Sequence
MKVEACTWAG YSGLYEAIES WDFKKIEKLE EYRLLLKRLQ PEFKTRIIPT DIISDLSECL 60
INQECEEILQ ICSTKGMMAG AEKLVECLLR SDKENWPKTL KLALEKERNK FSELWIVEKG 120
IKDVETEDLE DKMETSDIQI FYQEDPECQN LSENSCPPSE VSDTNLYSPF KPRNYQLELA 180
LPAMKGKNTI ICAPTGCGKT FVSLLICEHH LKKFPQGQKG KVVFFANQIP VYEQQKSVFS 240
KYFERHGYRV TGISGATAEN VPVEQIVENN DIIILTPQIL VNNLKKGTIP SLSIFTLMIF 300
DECHNTSKQH PYNMIMFNYL DQKLGGSSGP LPQVIGLTAS VGVGDAKNTD EALDYICKLC 360
ASLDASVIAT VKHNLEELEQ VVYKPQKFFR KVESRISDKF KYIIAQLMRD TESLAKRICK 420
DLENLSQIQN REFGTQKYEQ WIVTVQKACM VFQMPDKDEE SRICKALFLY TSHLRKYNDA 480
LIISEHARMK DALDYLKDFF SNVRAAGFDE IEQDLTQRFE EKLQELESVS RDPSNENPKL 540
EDLCFILQEE YHLNPETITI LFVKTRALVD ALKNWIEGNP KLSFLKPGIL TGRGKTNQNT 600
GMTLPAQKCI LDAFKASGDH NILIATSVAD EGIDIAQCNL VILYEYVGNV IKMIQTRGRG 660
RARGSKCFLL TSNAGVIEKE QINMYKEKMM NDSILRLQTW DEAVFREKIL HIQTHEKFIR 720
DSQEKPKPVP DKENKKLLCR KCKALACYTA DVRVIEECHY TVLGDAFKEC FVSRPHPKPK 780
QFSSFEKRAK IFCARQNCSH DWGIHVKYKT FEIPVIKIES FVVEDIATGV QTLYSKWKDF 840
HFEKIPFDPA EMSK 854 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR021673; RIG-I_C-RD. 
Pfam
 PF00270; DEAD
 PF00271; Helicase_C
 PF11648; RIG-I_C-RD 
SMART
 SM00382; AAA
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS