CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031022
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pyrroline-5-carboxylate reductase 
Protein Synonyms/Alias
  
Gene Name
 PYCR1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
242QALLGAAKMLLHSEQubiquitination[1, 2, 3]
255EQHPGQLKDNVSSPGubiquitination[1]
310QVSPAAIKKTILDKVubiquitination[1, 3, 4]
318KTILDKVKLDSPAGTubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Amino-acid biosynthesis; Complete proteome; NADP; Oxidoreductase; Proline biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 346 AA 
Protein Sequence
MVGGGRRVGR DEPVPSVGAL GQGSPDSMSV GFIGAGQLAF ALAKGFTAAG VLAAHKIMAS 60
SPDMDLATVS ALRKMGVKLT PHNKETVQHS DVLFLAVKPH IIPFILDEIG ADIEDRHIVV 120
SCAAGVTISS IEKKLSAFRP APRVIRCMTN TPVVVREGAT VYATGTHAQV EDGRLMEQLL 180
SSVGFCTEVE EDLIDAVTGL SGSGPAYAFT ALDALADGGV KMGLPRRLAV RLGAQALLGA 240
AKMLLHSEQH PGQLKDNVSS PGGATIHALH VLESGGFRSL LINAVEASCI RTRELQSMAD 300
QEQVSPAAIK KTILDKVKLD SPAGTALSPS GHTKLLPRSL APAGKD 346 
Gene Ontology
 GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:EC.
 GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR008927; 6-PGluconate_DH_C-like.
 IPR016040; NAD(P)-bd_dom.
 IPR004455; NADP_OxRdtase_F420.
 IPR000304; Pyrroline-COOH_reductase. 
Pfam
 PF03807; F420_oxidored 
SMART
  
PROSITE
 PS00521; P5CR 
PRINTS