CPLM-018102

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-018102

UniProt Accession

TMX1_MOUSE; Q8VBT0; Q3UCI8; Q9CSD5

Genbank Protein ID

AK013150; AK030429; AK050567; AK137059; AK150511; AK153027; AK170468; BC017603; BC021533

Genbank Nucleotide ID

BAB28680.3; BAC26960.1; BAC34326.1; BAE23223.1; BAE29624.1; BAE31660.1; BAE41816.1; AAH17603.1; AAH21533.1

Protein Name

Thioredoxin-related transmembrane protein 1

Protein Synonyms/Alias

Thioredoxin domain-containing protein 1

Gene Name

Tmx1

Gene Synonyms/Alias

Txndc; Txndc1

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
82	DLEVKVAKVDVTEQT	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.

Sequence Annotation

DOMAIN 27 132 Thioredoxin.
MOD_RES 245 245 Phosphoserine.
MOD_RES 256 256 Phosphoserine.
MOD_RES 278 278 Phosphoserine (By similarity).
DISULFID 56 59 Redox-active (By similarity).

Keyword

Complete proteome; Disulfide bond; Electron transport; Endoplasmic reticulum; Membrane; Phosphoprotein; Redox-active center; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

278 AA

Protein Sequence

MAHLGRLMVP LAALVLLLWA VPGAHGRRNN VRVLTDENWT SLLEGEWMIE FYAPWCPACQ 60
NLQPEWESFA EWGEDLEVKV AKVDVTEQTG LSGRFIITAL PSIYHCKDGE FRRYVGPRTK 120
KDFINFVSDK EWKNIEPISS WFGPSSVLMT MMSALFQLSV YIRTSHSYFV HDLGIPAWGS 180
YLVFAFATVL SGLLLGLCMI FVADCLCPSK RRKPQQQYAK KTSPEFSQPL KKVEEEQEAD 240
EEDVSEEEAE DREGASKATS QSSIRQRCVG LPSATDTS 278

Gene Ontology

GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0015036; F:disulfide oxidoreductase activity; IEA:Compara.
GO:0045454; P:cell redox homeostasis; IEA:InterPro.
GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.

Interpro

IPR012336; Thioredoxin-like_fold.
IPR017937; Thioredoxin_CS.
IPR013766; Thioredoxin_domain.

Pfam

PF00085; Thioredoxin

SMART

PROSITE

PS00194; THIOREDOXIN_1
PS51352; THIOREDOXIN_2

PRINTS