| Tag | Content |
|---|
| CPLM ID | CPLM-004451 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein groucho |
Protein Synonyms/Alias | Enhancer of split m9/10 protein; E(spl)m9/10 |
Gene Name | gro |
Gene Synonyms/Alias | E(spl)m9/m10; CG8384 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 233 | SKRRKDEKLQEDEGE | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Transcriptional corepressor that regulates transcription when recruited to specific target DNA by hairy-related bHLH proteins. Maternally required for neurogenesis; in the segregation of the neuroectoderm. Directly or indirectly interacts with Notch and Delta. |
Sequence Annotation | REPEAT 442 480 WD 1.
REPEAT 488 527 WD 2.
REPEAT 532 571 WD 3.
REPEAT 574 613 WD 4.
REPEAT 615 654 WD 5.
REPEAT 656 695 WD 6.
REPEAT 697 730 WD 7.
REGION 206 267 CCN domain.
REGION 262 425 Binding to basic helix-loop-helix domain.
MOTIF 227 230 Nuclear localization signal (Potential).
MOD_RES 205 205 Phosphoserine.
MOD_RES 207 207 Phosphoserine.
MOD_RES 218 218 Phosphoserine.
MOD_RES 242 242 Phosphoserine; by CK2 (Potential).
MOD_RES 258 258 Phosphoserine; by CDC2 (Potential).
MOD_RES 267 267 Phosphoserine.
MOD_RES 326 326 Phosphothreonine.
MOD_RES 328 328 Phosphothreonine. |
Keyword | Alternative splicing; Complete proteome; Developmental protein; Differentiation; Neurogenesis; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; WD repeat; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 730 AA |
Protein Sequence | MYPSPVRHPA AGGPPPQGPI KFTIADTLER IKEEFNFLQA QYHSIKLECE KLSNEKTEMQ 60
RHYVMYYEMS YGLNVEMHKQ TEIAKRLNTL INQLLPFLQA DHQQQVLQAV ERAKQVTMQE 120
LNLIIGHQQQ HGIQQLLQQI HAQQVPGGPP QPMGALNPFG ALGATMGLPH GPQGLLNKPP 180
EHHRPDIKPT GLEGPAAAEE RLRNSVSPAD REKYRTRSPL DIENDSKRRK DEKLQEDEGE 240
KSDQDLVVDV ANEMESHSPR PNGEHVSMEV RDRESLNGER LEKPSSSGIK QERPPSRSGS 300
SSSRSTPSLK TKDMEKPGTP GAKARTPTPN AAAPAPGVNP KQMMPQGPPP AGYPGAPYQR 360
PADPYQRPPS DPAYGRPPPM PYDPHAHVRT NGIPHPSALT GGKPAYSFHM NGEGSLQPVP 420
FPPDALVGVG IPRHARQINT LSHGEVVCAV TISNPTKYVY TGGKGCVKVW DISQPGNKNP 480
VSQLDCLQRD NYIRSVKLLP DGRTLIVGGE ASNLSIWDLA SPTPRIKAEL TSAAPACYAL 540
AISPDSKVCF SCCSDGNIAV WDLHNEILVR QFQGHTDGAS CIDISPDGSR LWTGGLDNTV 600
RSWDLREGRQ LQQHDFSSQI FSLGYCPTGD WLAVGMENSH VEVLHASKPD KYQLHLHESC 660
VLSLRFAACG KWFVSTGKDN LLNAWRTPYG ASIFQSKETS SVLSCDISTD DKYIVTGSGD 720
KKATVYEVIY 730 |
Gene Ontology | GO:0005634; C:nucleus; TAS:FlyBase. GO:0043234; C:protein complex; IPI:FlyBase. GO:0070491; F:repressing transcription factor binding; IGI:FlyBase. GO:0001106; F:RNA polymerase II transcription corepressor activity; IGI:FlyBase. GO:0007015; P:actin filament organization; IMP:FlyBase. GO:0048813; P:dendrite morphogenesis; IMP:FlyBase. GO:0046331; P:lateral inhibition; IMP:FlyBase. GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IDA:UniProtKB. GO:0045879; P:negative regulation of smoothened signaling pathway; IMP:FlyBase. GO:0007541; P:sex determination, primary response to X:A ratio; TAS:FlyBase. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |