CPLM-000914

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-000914

UniProt Accession

OPA1_HUMAN; O60313; D3DNW4

Genbank Protein ID

AB011139; HQ204906; HQ204907; HQ204908; HQ204910; HQ204911; HQ204912; HQ204913; HQ204914; HQ204917; HQ204918; HQ204920; HQ204921; HQ204922; HQ204923; HQ204924; HQ204925; HQ204926; HQ204927; HQ204929; HQ204930; HQ204932; HQ204933; HQ204934; HQ204935; HQ204936; HQ204938; HQ204939; HQ204940; HQ204941; HQ204942; HQ204943; HQ204944; HQ204945; AC048351; AC106710; CH471052; CH471052; BC075805; AF416919; AF416920

Genbank Nucleotide ID

BAA25493.1; ADP90057.1; ADP90065.1; ADP90073.1; ADP90089.1; ADP90097.1; ADP90105.1; ADP90113.1; ADP90121.1; ADP90145.1; ADP90153.1; ADP90169.1; ADP90177.1; ADP90185.1; ADP90193.1; ADP90201.1; ADP90209.1; ADP90217.1; ADP90225.1; ADP90241.1; ADP90249.1; ADP90265.1; ADP90273.1; ADP90281.1; ADP90289.1; ADP90297.1; ADP90313.1; ADP90321.1; ADP90329.1; ADP90337.1; ADP90345.1; ADP90353.1; ADP90361.1; ADP90369.1; EAW78064.1; EAW78071.1; AAH75805.1

Protein Name

Dynamin-like 120 kDa protein, mitochondrial

Protein Synonyms/Alias

Optic atrophy protein 1; Dynamin-like 120 kDa protein, form S1

Gene Name

OPA1

Gene Synonyms/Alias

KIAA0567

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
228	ELLHTQLKYQRILER	acetylation	[1]
228	ELLHTQLKYQRILER	ubiquitination	[2, 3]
568	EQQADSFKATRFNLE	ubiquitination	[3]

Reference

[1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
[2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space.

Sequence Annotation

NP_BIND 295 302 GTP (Potential).
NP_BIND 398 402 GTP (Potential).
NP_BIND 467 470 GTP (Potential).
MOD_RES 228 228 N6-acetyllysine.
MOD_RES 652 652 Phosphothreonine (By similarity).
MOD_RES 929 929 Phosphothreonine.

Keyword

Acetylation; Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Deafness; Disease mutation; GTP-binding; Hydrolase; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Sensory transduction; Transit peptide; Transmembrane; Transmembrane helix; Vision.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

960 AA

Protein Sequence

MWRLRRAAVA CEVCQSLVKH SSGIKGSLPL QKLHLVSRSI YHSHHPTLKL QRPQLRTSFQ 60
QFSSLTNLPL RKLKFSPIKY GYQPRRNFWP ARLATRLLKL RYLILGSAVG GGYTAKKTFD 120
QWKDMIPDLS EYKWIVPDIV WEIDEYIDFE KIRKALPSSE DLVKLAPDFD KIVESLSLLK 180
DFFTSGSPEE TAFRATDRGS ESDKHFRKVS DKEKIDQLQE ELLHTQLKYQ RILERLEKEN 240
KELRKLVLQK DDKGIHHRKL KKSLIDMYSE VLDVLSDYDA SYNTQDHLPR VVVVGDQSAG 300
KTSVLEMIAQ ARIFPRGSGE MMTRSPVKVT LSEGPHHVAL FKDSSREFDL TKEEDLAALR 360
HEIELRMRKN VKEGCTVSPE TISLNVKGPG LQRMVLVDLP GVINTVTSGM APDTKETIFS 420
ISKAYMQNPN AIILCIQDGS VDAERSIVTD LVSQMDPHGR RTIFVLTKVD LAEKNVASPS 480
RIQQIIEGKL FPMKALGYFA VVTGKGNSSE SIEAIREYEE EFFQNSKLLK TSMLKAHQVT 540
TRNLSLAVSD CFWKMVRESV EQQADSFKAT RFNLETEWKN NYPRLRELDR NELFEKAKNE 600
ILDEVISLSQ VTPKHWEEIL QQSLWERVST HVIENIYLPA AQTMNSGTFN TTVDIKLKQW 660
TDKQLPNKAV EVAWETLQEE FSRFMTEPKG KEHDDIFDKL KEAVKEESIK RHKWNDFAED 720
SLRVIQHNAL EDRSISDKQQ WDAAIYFMEE ALQARLKDTE NAIENMVGPD WKKRWLYWKN 780
RTQEQCVHNE TKNELEKMLK CNEEHPAYLA SDEITTVRKN LESRGVEVDP SLIKDTWHQV 840
YRRHFLKTAL NHCNLCRRGF YYYQRHFVDS ELECNDVVLF WRIQRMLAIT ANTLRQQLTN 900
TEVRRLEKNV KEVLEDFAED GEKKIKLLTG KRVQLAEDLK KVREIQEKLD AFIEALHQEK 960

Gene Ontology

GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0030061; C:mitochondrial crista; IDA:UniProtKB.
GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0003924; F:GTPase activity; TAS:UniProtKB.
GO:0000287; F:magnesium ion binding; NAS:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0019896; P:axon transport of mitochondrion; TAS:UniProtKB.
GO:0090398; P:cellular senescence; IDA:UniProtKB.
GO:0007007; P:inner mitochondrial membrane organization; IDA:UniProtKB.
GO:0000266; P:mitochondrial fission; TAS:UniProtKB.
GO:0008053; P:mitochondrial fusion; IDA:UniProtKB.
GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IMP:UniProtKB.
GO:0001843; P:neural tube closure; IEA:Compara.
GO:0007601; P:visual perception; IMP:UniProtKB.

Interpro

IPR022812; Dynamin.
IPR001401; Dynamin_GTPase.
IPR027417; P-loop_NTPase.

Pfam

PF00350; Dynamin_N

SMART

SM00053; DYNc

PROSITE

PS00410; DYNAMIN

PRINTS

PR00195; DYNAMIN.