| Tag | Content |
|---|
| CPLM ID | CPLM-012896 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin thioesterase OTU1 |
Protein Synonyms/Alias | |
Gene Name | Yod1 |
Gene Synonyms/Alias | Hshin7 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 252 | GEDAGYTKRVLLIYD | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di- ubiquitin (By similarity). |
Sequence Annotation | DOMAIN 144 269 OTU.
ZN_FING 313 337 C2H2-type.
REGION 45 123 UBX-like.
ACT_SITE 152 152 By similarity.
ACT_SITE 155 155 Nucleophile (By similarity).
ACT_SITE 337 337 By similarity. |
Keyword | Complete proteome; Hydrolase; Metal-binding; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway; Unfolded protein response; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 343 AA |
Protein Sequence | MFGGAKGGHF GVPPAGCSGA VSQAAAGTKA GPAGGRPADT MWRLRCKAKG GTHVLQGLSN 60
RTRLRELQGQ IAAITGIAPG SQRILVGYPP ECLDLSDRDI TLGDLPIQSG DMLIVEEDQT 120
RPKASPAFSK HGAPSYVRET LPVLTRTAVP ADNSCLFTSV YYVVEGGVLN PACAPEMRRL 180
IAQIVASDPD LYSEAILGKT NEEYCDWIRR DDTWGGAIEI SILSKFYQCE ICVVDTQTVR 240
IDRFGEDAGY TKRVLLIYDG IHYDPLQRNF PDPDTPPLTI FSSNDDIVLV QALELADEAR 300
RKRQFTDVNR FTLRCMLCQK GLTGQAEARD HARETGHTNF GEV 343 |
Gene Ontology | GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006520; P:cellular amino acid metabolic process; ISS:UniProtKB. GO:0030968; P:endoplasmic reticulum unfolded protein response; ISS:UniProtKB. GO:0030433; P:ER-associated protein catabolic process; ISS:UniProtKB. GO:0071108; P:protein K48-linked deubiquitination; ISS:UniProtKB. GO:0070536; P:protein K63-linked deubiquitination; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |