CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010358
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 7-cyano-7-deazaguanine synthase 
Protein Synonyms/Alias
 7-cyano-7-carbaguanine synthase; PreQ(0) synthase; Queuosine biosynthesis protein QueC 
Gene Name
 queC 
Gene Synonyms/Alias
 ybaX; b0444; JW0434 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
52VARELALKLGARAHKacetylation[1]
152AVSLGMAKDIRFETPacetylation[1]
177ALADYYGKLDLVRNEacetylation[1]
217LNHYLADKPTVMAAMacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity). 
Sequence Annotation
 NP_BIND 8 18 ATP (By similarity).
 METAL 188 188 Zinc (By similarity).
 METAL 197 197 Zinc (By similarity).
 METAL 200 200 Zinc (By similarity).
 METAL 203 203 Zinc (By similarity).  
Keyword
 ATP-binding; Complete proteome; Ligase; Metal-binding; Nucleotide-binding; Queuosine biosynthesis; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 231 AA 
Protein Sequence
MKRAVVVFSG GQDSTTCLVQ ALQQYDEVHC VTFDYGQRHR AEIDVARELA LKLGARAHKV 60
LDVTLLNELA VSSLTRDSIP VPDYEPEADG IPNTFVPGRN ILFLTLAAIY AYQVKAEAVI 120
TGVCETDFSG YPDCRDEFVK ALNHAVSLGM AKDIRFETPL MWIDKAETWA LADYYGKLDL 180
VRNETLTCYN GFKGDGCGHC AACNLRANGL NHYLADKPTV MAAMKQKTGL R 231 
Gene Ontology
 GO:0004055; F:argininosuccinate synthase activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0006526; P:arginine biosynthetic process; IEA:InterPro.
 GO:0008616; P:queuosine biosynthetic process; IGI:EcoCyc. 
Interpro
 IPR001518; Arginosuc_synth.
 IPR018317; QueC.
 IPR014729; Rossmann-like_a/b/a_fold. 
Pfam
 PF06508; ExsB 
SMART
  
PROSITE
  
PRINTS