CPLM-005940

Genbank Nucleotide ID

Phosphatidylethanolamine-binding protein 1

Protein Synonyms/Alias

PEBP-1; 23 kDa morphine-binding protein; HCNPpp; P23K; Hippocampal cholinergic neurostimulating peptide; HCNP

Rattus norvegicus (Rat)

Position	Peptide	Type	References
77	DPDAPSRKDPKFREW	acetylation	[1]
80	APSRKDPKFREWHHF	acetylation	[1]
113	YVGSGPPKDTGLHRY	acetylation	[1]
148	KSGDNRGKFKVESFR	acetylation	[1]
150	GDNRGKFKVESFRKK	acetylation	[1]

[1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]

Functional Description

Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity).

REGION 93 134 Interaction with RAF1 (By similarity).
MOD_RES 2 2 N-acetylalanine; in peptide hippocampal
MOD_RES 42 42 Phosphothreonine (By similarity).
MOD_RES 51 51 Phosphoserine (By similarity).
MOD_RES 52 52 Phosphoserine (By similarity).
MOD_RES 54 54 Phosphoserine (By similarity).

3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Lipid-binding; Membrane; Nucleotide-binding; Phosphoprotein; Protease inhibitor; Reference proteome; Serine protease inhibitor.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0045177; C:apical part of cell; IDA:RGD.
GO:0043679; C:axon terminus; IDA:RGD.
GO:0009986; C:cell surface; IDA:RGD.
GO:0005615; C:extracellular space; IDA:RGD.
GO:0005794; C:Golgi apparatus; IDA:RGD.
GO:0005741; C:mitochondrial outer membrane; IDA:RGD.
GO:0043025; C:neuronal cell body; IDA:RGD.
GO:0005791; C:rough endoplasmic reticulum; IDA:RGD.
GO:0008021; C:synaptic vesicle; IDA:RGD.
GO:0005524; F:ATP binding; IDA:RGD.
GO:0008289; F:lipid binding; TAS:RGD.
GO:0051019; F:mitogen-activated protein kinase binding; IDA:RGD.
GO:0005102; F:receptor binding; IDA:RGD.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
GO:0007568; P:aging; IEP:RGD.
GO:0007420; P:brain development; IEP:RGD.
GO:0042755; P:eating behavior; IEP:RGD.
GO:0000165; P:MAPK cascade; IDA:RGD.
GO:0043409; P:negative regulation of MAPK cascade; IMP:RGD.
GO:0001933; P:negative regulation of protein phosphorylation; IMP:RGD.
GO:0060409; P:positive regulation of acetylcholine metabolic process; IDA:RGD.
GO:0043950; P:positive regulation of cAMP-mediated signaling; IMP:RGD.
GO:0045840; P:positive regulation of mitosis; IMP:RGD.
GO:0001505; P:regulation of neurotransmitter levels; IDA:RGD.
GO:0002026; P:regulation of the force of heart contraction; IDA:RGD.
GO:0014823; P:response to activity; IEP:RGD.
GO:0051592; P:response to calcium ion; IEP:RGD.
GO:0051591; P:response to cAMP; IEP:RGD.
GO:0051412; P:response to corticosterone stimulus; IEP:RGD.
GO:0042493; P:response to drug; IEP:RGD.
GO:0051602; P:response to electrical stimulus; IEP:RGD.
GO:0045471; P:response to ethanol; IEP:RGD.
GO:0009408; P:response to heat; IEP:RGD.
GO:0006979; P:response to oxidative stress; IEP:RGD.
GO:0009636; P:response to toxic substance; IEP:RGD.
GO:0009611; P:response to wounding; IEP:RGD.
GO:0048240; P:sperm capacitation; IEA:Compara.
GO:0007286; P:spermatid development; IEP:RGD.

IPR001858; Phosphotidylethanolamine-bd_CS.
IPR008914; PtdEtn-bd_prot_PEBP.