CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045393
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Charged multivesicular body protein 2a 
Protein Synonyms/Alias
  
Gene Name
 CHMP2A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
52ADIKKMAKQGQMDAVubiquitination[1, 2, 3, 4]
64DAVRIMAKDLVRTRRubiquitination[1, 4]
89NIQAVSLKIQTLKSNubiquitination[1, 5]
94SLKIQTLKSNNSMAQubiquitination[1, 4, 5]
104NSMAQAMKGVTKAMGubiquitination[1, 4, 5]
108QAMKGVTKAMGTMNRubiquitination[1, 4]
118GTMNRQLKLPQIQKIubiquitination[1]
124LKLPQIQKIMMEFERubiquitination[1, 6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 159 AA 
Protein Sequence
MDLLFGRRKT PEELLRQNQR ALNRAMRELD RERQKLETQE KKIIADIKKM AKQGQMDAVR 60
IMAKDLVRTR RYVRKFVLMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM GTMNRQLKLP 120
QIQKIMMEFE RQAEIMDMKE EMMNDAIDDA MGDEEDEEE 159 
Gene Ontology
 GO:0015031; P:protein transport; IEA:InterPro. 
Interpro
 IPR005024; Snf7. 
Pfam
 PF03357; Snf7 
SMART
  
PROSITE
  
PRINTS