CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001574
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 
Protein Synonyms/Alias
 Complex I-42kD; CI-42kD; NADH-ubiquinone oxidoreductase 42 kDa subunit 
Gene Name
 NDUFA10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
48WHFLLGDKASKRLTEubiquitination[1]
102DSTTGDGKPLATDYNubiquitination[1]
242QDIENAYKKTFLPEMubiquitination[2]
243DIENAYKKTFLPEMSubiquitination[1]
277VEDIEYLKFDKGPWLubiquitination[1, 2, 3]
280IEYLKFDKGPWLKQDubiquitination[1]
285FDKGPWLKQDNRTLYubiquitination[1, 2, 3]
338FRELPGRKYSPGYNTubiquitination[3]
350YNTEVGDKWIWLK**ubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. 
Sequence Annotation
 MOD_RES 181 181 N6-acetyllysine (By similarity).
 MOD_RES 242 242 N6-acetyllysine (By similarity).
 MOD_RES 350 350 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Electron transport; FAD; Flavoprotein; Mitochondrion; Polymorphism; Reference proteome; Respiratory chain; Transit peptide; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 355 AA 
Protein Sequence
MALRLLKLAA TSASARVVAA GAQRVRGIHS SVQCKLRYGM WHFLLGDKAS KRLTERSRVI 60
TVDGNICTGK GKLAKEIAEK LGFKHFPEAG IHYPDSTTGD GKPLATDYNG NCSLEKFYDD 120
PRSNDGNSYR LQSWLYSSRL LQYSDALEHL LTTGQGVVLE RSIFSDFVFL EAMYNQGFIR 180
KQCVDHYNEV KSVTICDYLP PHLVIYIDVP VPEVQRRIQK KGDPHEMKIT SAYLQDIENA 240
YKKTFLPEMS EKCEVLQYSA REAQDSKKVV EDIEYLKFDK GPWLKQDNRT LYHLRLLVQD 300
KFEVLNYTSI PIFLPEVTIG AHQTDRVLHQ FRELPGRKYS PGYNTEVGDK WIWLK 355 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
 GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 
Interpro
 IPR002624; Deoxynucleoside_kinase.
 IPR015828; NADH_UbQ_OxRdtase_42KD_su.
 IPR027417; P-loop_NTPase. 
Pfam
 PF01712; dNK 
SMART
  
PROSITE
  
PRINTS