CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037191
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Peptidyl-prolyl cis-trans isomerase-like 2 
Protein Synonyms/Alias
  
Gene Name
 PPIL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
145QDPTNLDKFNVSNFYubiquitination[1, 2]
159YHVKNNMKIIDPDEEubiquitination[2]
169DPDEEKAKQDPSYYLubiquitination[3]
177QDPSYYLKNTNAETRubiquitination[2, 3]
192ETLQELYKEFKGDEIubiquitination[2]
211MKAPEKKKVDKLNAAubiquitination[2]
292NFIRLCKKHYYDGTIubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Isomerase; Reference proteome; Rotamase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 489 AA 
Protein Sequence
MGKRQHQKDK MYITCAEYTH FYGGKKPDLP QTNFRRLPFD HCRNIVPWLK KYGTNPSNGE 60
KLDGRSLIKL NFSKNSEGKY HCPVLFTVFT NNTHIVAVRT TGNVYAYEAV EQLNIKAKNF 120
RDLLTDEPFS RQDIITLQDP TNLDKFNVSN FYHVKNNMKI IDPDEEKAKQ DPSYYLKNTN 180
AETRETLQEL YKEFKGDEIL AATMKAPEKK KVDKLNAAHY STGKVSASFT STAMVPETTH 240
EAAAIDEDVL RYQFVKKKGY VRLHTNKGDL NLELHCDLTP KTCENFIRLC KKHYYDGTIF 300
HRSIRNFVIQ GGDPTGTGTG GESYWGKPFK DEFRPNLSHT GRGILSMANS GPNSNRSQFF 360
ITFRSCAYLD KKHTIFGRVV GGFDVLTAME NVESDPKTDR PKEEIRIDAT TVFVDPYEEA 420
DAQIAQERKT QLKEASSRGR ALNQCHCPHV QEEAQSGFWG LQLLVAAATC RLYLCPSFSH 480
QSLMLKLQA 489 
Gene Ontology
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC. 
Interpro
 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR020892; Cyclophilin-type_PPIase_CS.
 IPR026951; PPIL2. 
Pfam
 PF00160; Pro_isomerase 
SMART
  
PROSITE
 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2 
PRINTS
 PR00153; CSAPPISMRASE.