UniProt Accession

 AP3S_YEAST; P47064; D6VWF8 

Genbank Protein ID

 U31448; Z49299; BK006943 

Genbank Nucleotide ID

 AAA92051.1; CAA89315.1; DAA08774.1 

Protein Name

 AP-3 complex subunit sigma 

Protein Synonyms/Alias

 AP-3 complex sigma3A subunit; Adapter-related protein complex 3 sigma subunit; Clathrin-associated/assembly/adapter protein, small 3; Sigma-adaptin 3A; Sigma3-adaptin 

Gene Name

 APS3 

Gene Synonyms/Alias

 YKS7; YJL024C; J1274 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
166	AAESTDSKIGRLTST	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasmic vesicle; Golgi apparatus; Membrane; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 194 AA 

Protein Sequence

Gene Ontology

 GO:0030123; C:AP-3 adaptor complex; IMP:SGD.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0006896; P:Golgi to vacuole transport; IMP:SGD.
 GO:0006623; P:protein targeting to vacuole; IMP:SGD. 

Interpro

 IPR016635; AP_complex_ssu.
 IPR022775; AP_mu_sigma_su.
 IPR027155; APS3.
 IPR000804; Clathrin_sm-chain_CS.
 IPR011012; Longin-like_dom. 

Pfam

 PF01217; Clat_adaptor_s 

SMART

  

PROSITE

 PS00989; CLAT_ADAPTOR_S 

PRINTS