UniProt Accession

 HNRCL_HUMAN; O60812; B2RP44 

Genbank Protein ID

 AL022101; CH471130; BC137258; BC171866 

Genbank Nucleotide ID

 CAA17879.1; EAW71752.1; AAI37259.1; AAI71866.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein C-like 1 

Protein Synonyms/Alias

 hnRNP C-like-1; hnRNP core protein C-like 1 

Gene Name

 HNRNPCL1 

Gene Synonyms/Alias

 HNRPCL1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
29	NLNTLVVKKSDVEAI	ubiquitination	[1]
39	DVEAIFSKYGKIAGC	acetylation	[2]
39	DVEAIFSKYGKIAGC	ubiquitination	[1]
157	GNTSRRGKSGFNSKS	acetylation	[2]
193	ELTQIKQKVDSLLEN	ubiquitination	[1]
203	SLLENLEKIEKEQSK	acetylation	[2]
203	SLLENLEKIEKEQSK	ubiquitination	[1]
237	KKDETHVKMESEGGA	sumoylation	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] SUMO modification of heterogeneous nuclear ribonucleoproteins.
 Vassileva MT, Matunis MJ.
 Mol Cell Biol. 2004 May;24(9):3623-32. [PMID: 15082759] 

Functional Description

 May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs (By similarity). 

Sequence Annotation

 DOMAIN 16 87 RRM.  

Keyword

 Complete proteome; Nucleus; Polymorphism; Reference proteome; Ribonucleoprotein; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 293 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 

Interpro

 IPR017347; hnRNP_C_Raly.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS