UniProt Accession

 TEF_RAT; P41224; Q3T1I8 

Genbank Protein ID

 BC101895; S58745 

Genbank Nucleotide ID

 AAI01896.1; AAB20032.1 

Protein Name

 Thyrotroph embryonic factor 

Protein Synonyms/Alias

  

Gene Name

 Tef 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
38	GSFPLVLKKLMENPP	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'- [TC][AG][AG]TTA[TC][AG]-3'. 

Sequence Annotation

 DOMAIN 231 294 bZIP.
 REGION 233 253 Basic motif (By similarity).
 REGION 254 261 Leucine-zipper (By similarity).
 MOD_RES 30 30 Phosphoserine (By similarity).  

Keyword

 Activator; Biological rhythms; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 301 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:RGD.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0046982; F:protein heterodimerization activity; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:RGD.
 GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004827; bZIP. 

Pfam

 PF07716; bZIP_2 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS