CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014036
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein lin-9 homolog 
Protein Synonyms/Alias
 HuLin-9; hLin-9; Beta subunit-associated regulator of apoptosis; TUDOR gene similar protein; Type I interferon receptor beta chain-associated protein; pRB-associated protein 
Gene Name
 LIN9 
Gene Synonyms/Alias
 BARA; TGS 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
32LSNTWNEKYSSLQKTubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. 
Sequence Annotation
 REGION 2 296 Sufficient for interaction with RB1.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 65 65 Phosphoserine.
 MOD_RES 304 304 Phosphothreonine.
 MOD_RES 309 309 Phosphoserine.
 MOD_RES 321 321 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Cell cycle; Coiled coil; Complete proteome; DNA synthesis; Nucleus; Phosphoprotein; Reference proteome; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 542 AA 
Protein Sequence
MAELDQLPDE SSSAKALVSL KEGSLSNTWN EKYSSLQKTP VWKGRNTSSA VEMPFRNSKR 60
SRLFSDEDDR QINTRSPKRN QRVAMVPQKF TATMSTPDKK ASQKIGFRLR NLLKLPKAHK 120
WCIYEWFYSN IDKPLFEGDN DFCVCLKESF PNLKTRKLTR VEWGKIRRLM GKPRRCSSAF 180
FEEERSALKQ KRQKIRLLQQ RKVADVSQFK DLPDEIPLPL VIGTKVTARL RGVHDGLFTG 240
QIDAVDTLNA TYRVTFDRTG LGTHTIPDYE VLSNEPHETM PIAAFGQKQR PSRFFMTPPR 300
LHYTPPLQSP IIDNDPLLGQ SPWRSKISGS DTETLGGFPV EFLIQVTRLS KILMIKKEHI 360
KKLREMNTEA EKLKSYSMPI SIEFQRRYAT IVLELEQLNK DLNKVLHKVQ QYCYELAPDQ 420
GLQPADQPTD MRRRCEEEAQ EIVRHANSST GQPCVENENL TDLISRLTAI LLQIKCLAEG 480
GDLNSFEFKS LTDSLNDIKS TIDASNISCF QNNVEIHVAH IQSGLSQMGN LHAFAANNTN 540
RD 542 
Gene Ontology
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome. 
Interpro
 IPR010561; DIRP. 
Pfam
 PF06584; DIRP 
SMART
  
PROSITE
  
PRINTS