CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029427
UniProt Accession
Genbank Protein ID
 U52111 
Genbank Nucleotide ID
  
Protein Name
 SRSF protein kinase 3 
Protein Synonyms/Alias
  
Gene Name
 SRPK3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
86VDEIKLLKCVRDSDPubiquitination[1]
343GNACWVHKHFTEDIQubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 492 AA 
Protein Sequence
MLQGLLGSDD EEQEDPKDYC KGGYHPVKIG DVFNGRYHVV RKLGWGHFST VWLCWDIQRK 60
RFVALKVVKS AGHYTETAVD EIKLLKCVRD SDPSDPKRET IVQLIDDFRI SGVNGVHVCM 120
VLEVLGHQLL KWIIKSNYQG LPVPCVKSIV RQVLHGLDYL HTKCKIIHTD IKPENILLCV 180
GDAYIRRLAA EATEWQQAGA PPPSRSIVST APQEVLTGKL SKNKRKKMRR KRKQQKRLLE 240
ERLRDLQRLE AMEAATQAED SGLRLDGGSG STSSSGCFSG SLFSPASCSI LSGSSNQRET 300
GGLLSPSTPF GASNLLVNPL EPQNADKIKI KIADLGNACW VHKHFTEDIQ TRQYRAVEVL 360
IGAEYGPPAD IWSTACMAFE LATGDYLFEP HSGEDYSRDE DHIAHIVELL GDIPPAFALS 420
GRYSREFFNR RGELRHIHNL KHWGLYEVLM EKYEWPLEQA TQFSAFLLPM MEYIPEKRAS 480
AADCLQHPWL NP 492 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS