CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004052
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cadherin-1 
Protein Synonyms/Alias
 CAM 120/80; Epithelial cadherin; E-cadherin; Uvomorulin; CD324; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3 
Gene Name
 CDH1 
Gene Synonyms/Alias
 CDHE; UVO 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
738LRRRAVVKEPLLPPEubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. 
Sequence Annotation
 DOMAIN 155 262 Cadherin 1.
 DOMAIN 263 375 Cadherin 2.
 DOMAIN 376 486 Cadherin 3.
 DOMAIN 487 593 Cadherin 4.
 DOMAIN 594 697 Cadherin 5.
 REGION 758 769 Required for binding CTNND1 and PSEN1.
 REGION 811 882 Required for binding alpha, beta and
 METAL 257 257 Calcium 1.
 METAL 257 257 Calcium 2.
 METAL 288 288 Calcium 3.
 MOD_RES 753 753 Phosphotyrosine; by SRC.
 MOD_RES 754 754 Phosphotyrosine; by SRC.
 MOD_RES 755 755 Phosphotyrosine; by SRC.
 MOD_RES 838 838 Phosphoserine (By similarity).
 MOD_RES 840 840 Phosphoserine (By similarity).
 MOD_RES 846 846 Phosphoserine (By similarity).
 CARBOHYD 558 558 N-linked (GlcNAc...).
 CARBOHYD 570 570 N-linked (GlcNAc...).
 CARBOHYD 622 622 N-linked (GlcNAc...).
 CARBOHYD 637 637 N-linked (GlcNAc...).
 DISULFID 163 163 Interchain.  
Keyword
 3D-structure; Calcium; Cell adhesion; Cell junction; Cell membrane; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Endosome; Glycoprotein; Golgi apparatus; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 882 AA 
Protein Sequence
MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC 60
TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG 120
HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQIKS 180
NKDKEGKVFY SITGQGADTP PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN 240
AVEDPMEILI TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI 300
AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL QGEGLSTTAT 360
AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD ADAPNTPAWE AVYTILNDDG 420
GQFVVTTNPV NNDGILKTAK GLDFEAKQQY ILHVAVTNVV PFEVSLTTST ATVTVDVLDV 480
NEAPIFVPPE KRVEVSEDFG VGQEITSYTA QEPDTFMEQK ITYRIWRDTA NWLEINPDTG 540
AISTRAELDR EDFEHVKNST YTALIIATDN GSPVATGTGT LLLILSDVND NAPIPEPRTI 600
FFCERNPKPQ VINIIDADLP PNTSPFTAEL THGASANWTI QYNDPTQESI ILKPKMALEV 660
GDYKINLKLM DNQNKDQVTT LEVSVCDCEG AAGVCRKAQP VEAGLQIPAI LGILGGILAL 720
LILILLLLLF LRRRAVVKEP LLPPEDDTRD NVYYYDEEGG GEEDQDFDLS QLHRGLDARP 780
EVTRNDVAPT LMSVPRYLPR PANPDEIGNF IDENLKAADT DPTAPPYDSL LVFDYEGSGS 840
EAASLSSLNS SESDKDQDYD YLNEWGNRFK KLADMYGGGE DD 882 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:BHF-UCL.
 GO:0016235; C:aggresome; IDA:HPA.
 GO:0043296; C:apical junction complex; IDA:UniProtKB.
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0043679; C:axon terminus; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0016342; C:catenin complex; IDA:BHF-UCL.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
 GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
 GO:0005925; C:focal adhesion; IDA:HPA.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IDA:BHF-UCL.
 GO:0009898; C:internal side of plasma membrane; IDA:UniProtKB.
 GO:0043219; C:lateral loop; IEA:Compara.
 GO:0016328; C:lateral plasma membrane; IDA:BHF-UCL.
 GO:0033268; C:node of Ranvier; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
 GO:0043220; C:Schmidt-Lanterman incisure; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IMP:BHF-UCL.
 GO:0008013; F:beta-catenin binding; IDA:BHF-UCL.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0050839; F:cell adhesion molecule binding; NAS:BHF-UCL.
 GO:0034332; P:adherens junction organization; TAS:Reactome.
 GO:0034329; P:cell junction assembly; TAS:Reactome.
 GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
 GO:0071230; P:cellular response to amino acid stimulus; IEA:Compara.
 GO:0071681; P:cellular response to indole-3-methanol; IDA:UniProtKB.
 GO:0071285; P:cellular response to lithium ion; IDA:UniProtKB.
 GO:0090102; P:cochlea development; IEA:Compara.
 GO:0007156; P:homophilic cell adhesion; NAS:UniProtKB.
 GO:0022408; P:negative regulation of cell-cell adhesion; IMP:UniProtKB.
 GO:0031175; P:neuron projection development; IEA:Compara.
 GO:0021983; P:pituitary gland development; IEA:Compara.
 GO:0042993; P:positive regulation of transcription factor import into nucleus; IDA:BHF-UCL.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0072659; P:protein localization to plasma membrane; IDA:BHF-UCL.
 GO:0019538; P:protein metabolic process; IEA:Compara.
 GO:0060693; P:regulation of branching involved in salivary gland morphogenesis; IEA:Compara.
 GO:0043281; P:regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0050776; P:regulation of immune response; TAS:Reactome.
 GO:2000008; P:regulation of protein localization to cell surface; IEA:Compara.
 GO:0033561; P:regulation of water loss via skin; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0060662; P:salivary gland cavitation; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IEA:Compara.
 GO:0007416; P:synapse assembly; IEA:Compara.
 GO:0070830; P:tight junction assembly; IEA:Compara.
 GO:0001829; P:trophectodermal cell differentiation; IEA:Compara. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR020894; Cadherin_CS.
 IPR000233; Cadherin_cytoplasmic-dom.
 IPR014868; Cadherin_pro_dom.
 IPR027397; Catenin_binding_dom. 
Pfam
 PF00028; Cadherin
 PF01049; Cadherin_C
 PF08758; Cadherin_pro 
SMART
 SM00112; CA
 SM01055; Cadherin_pro 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.